Effects of an intensive long-term prevention programme after myocardial infarction – a randomized trial

Harm Wienbergen*, Andreas Fach, Sven Meyer, Jochen Meyer, Janina Stehmeier, Tina Backhaus, Stephan Michel, Kirsten Krämer, Rico Osteresch, Johannes Schmucker, Henning Haase, Tobias Härle, Albrecht Elsässer, Rainer Hambrecht

*Corresponding author for this work
2 Citations (Scopus)


BACKGROUND: Long-term risk factor control after myocardial infarction (MI) is currently inadequate and there is an unmet need for effective secondary prevention programmes.

DESIGN AND METHODS: It was the aim of the study to compare a 12-month intensive prevention programme (IPP), coordinated by prevention assistants and including education sessions, telephone visits and telemetric risk factor control, with usual care after MI. Three hundred and ten patients were randomized to IPP vs. usual care one month after hospital discharge for MI in two German heart centres. Primary study endpoint was the IPP Prevention Score (0-15 points) quantifying global risk factor control.

RESULTS: Global risk factor control was strongly improved directly after MI before the beginning of the randomized study (30% increase IPP Prevention Score). During the 12-month course of the randomized trial the IPP Prevention Score was improved by a further 14.3% in the IPP group ( p < 0.001), while it decreased by 11.8% in the usual care group ( p < 0.001). IPP significantly reduced smoking, low-density lipoprotein cholesterol, systolic blood pressure and physical inactivity compared with usual care ( p < 0.05). Step counters with online documentation were used by the majority of patients (80%). Quality of life was significantly improved by IPP ( p < 0.05). The composite endpoint of adverse clinical events was slightly lower in the IPP group during 12 months (13.8% vs. 18.9%, p = 0.25).

CONCLUSIONS: A novel intensive prevention programme after MI, coordinated by prevention assistants and using personal teachings and telemetric strategies for 12 months, was significantly superior to usual care in providing sustainable risk factor control and better quality of life.

Original languageEnglish
JournalEuropean Journal of Preventive Cardiology
Issue number5
Pages (from-to)522-530
Number of pages9
Publication statusPublished - 01.03.2019

Research Areas and Centers

  • Academic Focus: Center for Brain, Behavior and Metabolism (CBBM)


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