Effects of Alprazolam and Bromazepam on Visual Search and Verbal Recognition Memory in Humans: A Study with Event-Related Brain Potentials

Thomas F. Münte; Eckhard Gehde; Sönke Johannes; Manuel Seewald; Hans Jochen Heinze

doi:10.1159/000119291

Effects of Alprazolam and Bromazepam on Visual Search and Verbal Recognition Memory in Humans: A Study with Event-Related Brain Potentials

Thomas F. Münte^*, Eckhard Gehde, Sönke Johannes, Manuel Seewald, Hans Jochen Heinze

^*Corresponding author for this work

16 Citations (Scopus)

Abstract

The effects of two benzodiazepines (alprazolam and bromazepam) on performance and event-related brain potentials (ERPs) in visual search and verbal recognition memory paradigms were tested in a placebo-controlled double-blind paradigm employing 12 young healthy subjects. Both drugs exerted similar effects on performance and electrophysiological measures. Reaction times and hit rates were adversely affected in both paradigms. The ERP pattern in the visual search experiment suggested an impairment in selective attention (reduction of Nl component) and of automatic feature registration (posterior N2 reduction). In the world recognition experiment a dramatic reduction of the N400 component was seen under benzodiazepines. This is interpreted as reflecting an impaired ability to perform context integration processes.

Original language	English
Journal	Neuropsychobiology
Volume	34
Issue number	1
Pages (from-to)	49-56
Number of pages	8
ISSN	0302-282X
DOIs	https://doi.org/10.1159/000119291
Publication status	Published - 01.01.1996

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Academic Focus: Center for Brain, Behavior and Metabolism (CBBM)

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AU - Seewald, Manuel

AU - Heinze, Hans Jochen

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Effects of Alprazolam and Bromazepam on Visual Search and Verbal Recognition Memory in Humans: A Study with Event-Related Brain Potentials

Abstract

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