Effectiveness and toxicity of single-fraction radiotherapy with 1x8 Gy for metastatic spinal cord compression

Dirk Rades; Lukas J.A. Stalpers; Maarten C.C.M. Hulshof; Oliver Zschenker; Winfried Alberti; Caro C.E. Koning

doi:10.1016/j.radonc.2004.12.013

Effectiveness and toxicity of single-fraction radiotherapy with 1x8 Gy for metastatic spinal cord compression

Dirk Rades^*, Lukas J.A. Stalpers, Maarten C.C.M. Hulshof, Oliver Zschenker, Winfried Alberti, Caro C.E. Koning

^*Corresponding author for this work

Department of Radiotherapy

24 Citations (Scopus)

Abstract

Toxicity and functional outcome were evaluated in 199 MSCC-patients irradiated with 1×8 Gy. Motor function improved in 54/199 patients (27%). Patients who regained walking ability were 20/78 (26%). Long-term-survivors (≥12 months) who needed re-irradiation for in-field-recurrence were 19/65 (29%). Acute toxicity was mild, late toxicity not observed. A randomised trial comparing single-fraction RT to multi-fraction RT is mandatory.

Original language	English
Journal	Radiotherapy and Oncology
Volume	75
Issue number	1
Pages (from-to)	70-73
Number of pages	4
ISSN	0167-8140
DOIs	https://doi.org/10.1016/j.radonc.2004.12.013
Publication status	Published - 2005

Funding

The authors would like to thank Mrs M. van der Kar for her assistance in logistics and organisation. This project was supported by the ESTRO (EDRO Technology Transfer Grant).

UN SDGs

This output contributes to the following UN Sustainable Development Goals (SDGs)

SDG 3 Good Health and Well-being

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10.1016/j.radonc.2004.12.013

Cite this

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title = "Effectiveness and toxicity of single-fraction radiotherapy with 1x8 Gy for metastatic spinal cord compression",

abstract = "Toxicity and functional outcome were evaluated in 199 MSCC-patients irradiated with 1×8 Gy. Motor function improved in 54/199 patients (27\%). Patients who regained walking ability were 20/78 (26\%). Long-term-survivors (≥12 months) who needed re-irradiation for in-field-recurrence were 19/65 (29\%). Acute toxicity was mild, late toxicity not observed. A randomised trial comparing single-fraction RT to multi-fraction RT is mandatory.",

author = "Dirk Rades and Stalpers, \{Lukas J.A.\} and Hulshof, \{Maarten C.C.M.\} and Oliver Zschenker and Winfried Alberti and Koning, \{Caro C.E.\}",

note = "Funding Information: The authors would like to thank Mrs M. van der Kar for her assistance in logistics and organisation. This project was supported by the ESTRO (EDRO Technology Transfer Grant). Copyright: Copyright 2008 Elsevier B.V., All rights reserved.",

year = "2005",

doi = "10.1016/j.radonc.2004.12.013",

language = "English",

volume = "75",

pages = "70--73",

journal = "Radiotherapy and Oncology",

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TY - JOUR

T1 - Effectiveness and toxicity of single-fraction radiotherapy with 1x8 Gy for metastatic spinal cord compression

AU - Rades, Dirk

AU - Stalpers, Lukas J.A.

AU - Hulshof, Maarten C.C.M.

AU - Zschenker, Oliver

AU - Alberti, Winfried

AU - Koning, Caro C.E.

N1 - Funding Information: The authors would like to thank Mrs M. van der Kar for her assistance in logistics and organisation. This project was supported by the ESTRO (EDRO Technology Transfer Grant). Copyright: Copyright 2008 Elsevier B.V., All rights reserved.

PY - 2005

Y1 - 2005

N2 - Toxicity and functional outcome were evaluated in 199 MSCC-patients irradiated with 1×8 Gy. Motor function improved in 54/199 patients (27%). Patients who regained walking ability were 20/78 (26%). Long-term-survivors (≥12 months) who needed re-irradiation for in-field-recurrence were 19/65 (29%). Acute toxicity was mild, late toxicity not observed. A randomised trial comparing single-fraction RT to multi-fraction RT is mandatory.

AB - Toxicity and functional outcome were evaluated in 199 MSCC-patients irradiated with 1×8 Gy. Motor function improved in 54/199 patients (27%). Patients who regained walking ability were 20/78 (26%). Long-term-survivors (≥12 months) who needed re-irradiation for in-field-recurrence were 19/65 (29%). Acute toxicity was mild, late toxicity not observed. A randomised trial comparing single-fraction RT to multi-fraction RT is mandatory.

UR - https://www.scopus.com/pages/publications/18144377397

U2 - 10.1016/j.radonc.2004.12.013

DO - 10.1016/j.radonc.2004.12.013

M3 - Journal articles

C2 - 15878103

AN - SCOPUS:18144377397

SN - 0167-8140

VL - 75

SP - 70

EP - 73

JO - Radiotherapy and Oncology

JF - Radiotherapy and Oncology

IS - 1

ER -

Effectiveness and toxicity of single-fraction radiotherapy with 1x8 Gy for metastatic spinal cord compression

Abstract

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UN SDGs

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