TY - JOUR
T1 - Effect of breastfeeding duration on lung function, respiratory symptoms and allergic diseases in school-age children
AU - Gorlanova, Olga
AU - Appenzeller, Rhea
AU - Mahmoud, Yasmin S.
AU - Ramsey, Kathryn A.
AU - Usemann, Jakob
AU - Decrue, Fabienne
AU - Kuehni, Claudia E.
AU - Röösli, Martin
AU - Latzin, Philipp
AU - Fuchs, Oliver
AU - Soti, Andras
AU - Frey, Urs
N1 - Funding Information:
We would like to thank our study participants and their families for their participation. We also thank also Karine Bell Hugentobler for proofreading the manuscript. Furthermore, we thank the BILD study nurses for their invaluable assistance and support.
Publisher Copyright:
© 2020 Wiley Periodicals, Inc.
Copyright:
Copyright 2020 Elsevier B.V., All rights reserved.
PY - 2020/6/1
Y1 - 2020/6/1
N2 - Background: A positive effect of breastfeeding on lung function has been demonstrated in cohorts of children with asthma or risk for asthma. We assessed the impact of breastfeeding on lung function and symptoms at the age of 6 years in an unselected, healthy birth cohort. Methods: We prospectively studied healthy term infants from the Bern-Basel Infant Lung Development (BILD) cohort from birth up to 6 years. Any breastfeeding was assessed by weekly phone calls during the first year of life. Risk factors (eg, smoking exposure, parental history of allergic conditions, and education) were obtained using standardized questionnaires. The primary outcomes were lung function parameters measured at 6 years of age by spirometry forced expiratory volume in 1 second, body plethysmography (functional residual capacity [FRCpleth], the total lung capacity [TLCpleth], and the effective respiratory airway resistance [Reff]) and fractional exhaled nitric oxide (FeNO). Secondary outcomes included ever wheeze (between birth and 6 years), wheeze in the past 12 months, asthma, presence of allergic conditions, atopic dermatitis, rhinitis, and positive skin prick test at the age of 6 years. Results: In 377 children the mean breastfeeding duration was 36 weeks (SD 14.4). We found no association of breastfeeding duration with obstructive or restrictive lung function and FeNO. After adjustment for confounders, we found no associations of breastfeeding duration with respiratory symptoms or the presence of allergic conditions. Conclusion: This study found no evidence of an association between breastfeeding and comprehensive lung function in unselected healthy children with long-term breastfeeding. Our findings do not support the hypothesis that the duration of breastfeeding has a direct impact on lung function in a healthy population with low asthmatic risk.
AB - Background: A positive effect of breastfeeding on lung function has been demonstrated in cohorts of children with asthma or risk for asthma. We assessed the impact of breastfeeding on lung function and symptoms at the age of 6 years in an unselected, healthy birth cohort. Methods: We prospectively studied healthy term infants from the Bern-Basel Infant Lung Development (BILD) cohort from birth up to 6 years. Any breastfeeding was assessed by weekly phone calls during the first year of life. Risk factors (eg, smoking exposure, parental history of allergic conditions, and education) were obtained using standardized questionnaires. The primary outcomes were lung function parameters measured at 6 years of age by spirometry forced expiratory volume in 1 second, body plethysmography (functional residual capacity [FRCpleth], the total lung capacity [TLCpleth], and the effective respiratory airway resistance [Reff]) and fractional exhaled nitric oxide (FeNO). Secondary outcomes included ever wheeze (between birth and 6 years), wheeze in the past 12 months, asthma, presence of allergic conditions, atopic dermatitis, rhinitis, and positive skin prick test at the age of 6 years. Results: In 377 children the mean breastfeeding duration was 36 weeks (SD 14.4). We found no association of breastfeeding duration with obstructive or restrictive lung function and FeNO. After adjustment for confounders, we found no associations of breastfeeding duration with respiratory symptoms or the presence of allergic conditions. Conclusion: This study found no evidence of an association between breastfeeding and comprehensive lung function in unselected healthy children with long-term breastfeeding. Our findings do not support the hypothesis that the duration of breastfeeding has a direct impact on lung function in a healthy population with low asthmatic risk.
UR - http://www.scopus.com/inward/record.url?scp=85081971816&partnerID=8YFLogxK
U2 - 10.1002/ppul.24733
DO - 10.1002/ppul.24733
M3 - Journal articles
C2 - 32181595
AN - SCOPUS:85081971816
SN - 8755-6863
VL - 55
SP - 1448
EP - 1455
JO - Pediatric Pulmonology
JF - Pediatric Pulmonology
IS - 6
ER -