Early right ventricular systolic dysfunction in patients with systemic sclerosis without pulmonary hypertension: A Doppler Tissue and Speckle Tracking echocardiography study

Sebastian Schattke; Fabian Knebel; Andrea Grohmann; Henryk Dreger; Friederike Kmezik; Gabriela Riemekasten; Gert Baumann; Adrian C. Borges

doi:10.1186/1476-7120-8-3

Early right ventricular systolic dysfunction in patients with systemic sclerosis without pulmonary hypertension: A Doppler Tissue and Speckle Tracking echocardiography study

Sebastian Schattke^*, Fabian Knebel, Andrea Grohmann, Henryk Dreger, Friederike Kmezik, Gabriela Riemekasten, Gert Baumann, Adrian C. Borges

^*Corresponding author for this work

Department of Rheumatology and Clinical Immunology

Charite - Universitatsmedizin Berlin

59 Citations (Scopus)

Abstract

Background. Isovolumetric acceleration (IVA) is a novel tissue Doppler parameter for the assessment of systolic function. The aim of this study was to evaluate IVA as an early parameter for the detection of right ventricular (RV) systolic dysfunction in patients with systemic sclerosis (SSc) without pulmonary hypertension. Methods. 22 patients and 22 gender- and age-matched healthy subjects underwent standard echocardiography with tissue Doppler imaging (TDI) and speckle tracking strain to assess RV function. Results. Tricuspid annular plane systolic excursion (TAPSE) (23.2 ± 4.1 mm vs. 26.5 ± 2.9 mm, p < 0.006), peak myocardial systolic velocity (Sm) (11.6 ± 2.3 cm/s vs. 13.9 ± 2.7 cm/s, p = 0.005), isovolumetric contraction velocity (IVV) (10.3 3 cm/s vs. 14.8 3 cm/s, p < 0.001) and IVA (2.3 ± 0.4 m/s ² vs. 4.1 ± 0.8 m/s², p < 0.001) were significant lower in the patient group. IVA was the best parameter to predict early systolic dysfunction with an area under the curve of 0.988. Conclusion. IVA is a useful tool with high-predictive power to detect early right ventricular systolic impairment in patients with SSc and without pulmonary hypertension.

Original language	English
Article number	3
Journal	Cardiovascular Ultrasound
Volume	8
Issue number	1
DOIs	https://doi.org/10.1186/1476-7120-8-3
Publication status	Published - 2010

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This output contributes to the following UN Sustainable Development Goals (SDGs)

SDG 3 Good Health and Well-being

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Academic Focus: Center for Infection and Inflammation Research (ZIEL)

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10.1186/1476-7120-8-3

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Schattke, S., Knebel, F., Grohmann, A., Dreger, H., Kmezik, F., Riemekasten, G., Baumann, G., & Borges, A. C. (2010). Early right ventricular systolic dysfunction in patients with systemic sclerosis without pulmonary hypertension: A Doppler Tissue and Speckle Tracking echocardiography study. Cardiovascular Ultrasound, 8(1), Article 3. https://doi.org/10.1186/1476-7120-8-3

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title = "Early right ventricular systolic dysfunction in patients with systemic sclerosis without pulmonary hypertension: A Doppler Tissue and Speckle Tracking echocardiography study",

abstract = "Background. Isovolumetric acceleration (IVA) is a novel tissue Doppler parameter for the assessment of systolic function. The aim of this study was to evaluate IVA as an early parameter for the detection of right ventricular (RV) systolic dysfunction in patients with systemic sclerosis (SSc) without pulmonary hypertension. Methods. 22 patients and 22 gender- and age-matched healthy subjects underwent standard echocardiography with tissue Doppler imaging (TDI) and speckle tracking strain to assess RV function. Results. Tricuspid annular plane systolic excursion (TAPSE) (23.2 ± 4.1 mm vs. 26.5 ± 2.9 mm, p < 0.006), peak myocardial systolic velocity (Sm) (11.6 ± 2.3 cm/s vs. 13.9 ± 2.7 cm/s, p = 0.005), isovolumetric contraction velocity (IVV) (10.3 3 cm/s vs. 14.8 3 cm/s, p < 0.001) and IVA (2.3 ± 0.4 m/s 2 vs. 4.1 ± 0.8 m/s2, p < 0.001) were significant lower in the patient group. IVA was the best parameter to predict early systolic dysfunction with an area under the curve of 0.988. Conclusion. IVA is a useful tool with high-predictive power to detect early right ventricular systolic impairment in patients with SSc and without pulmonary hypertension.",

author = "Sebastian Schattke and Fabian Knebel and Andrea Grohmann and Henryk Dreger and Friederike Kmezik and Gabriela Riemekasten and Gert Baumann and Borges, \{Adrian C.\}",

year = "2010",

doi = "10.1186/1476-7120-8-3",

language = "English",

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journal = "Cardiovascular Ultrasound",

issn = "1476-7120",

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Early right ventricular systolic dysfunction in patients with systemic sclerosis without pulmonary hypertension: A Doppler Tissue and Speckle Tracking echocardiography study. / Schattke, Sebastian; Knebel, Fabian; Grohmann, Andrea et al.
In: Cardiovascular Ultrasound, Vol. 8, No. 1, 3, 2010.

Research output: Journal Articles › Journal articles › Research › peer-review

TY - JOUR

T1 - Early right ventricular systolic dysfunction in patients with systemic sclerosis without pulmonary hypertension: A Doppler Tissue and Speckle Tracking echocardiography study

AU - Schattke, Sebastian

AU - Knebel, Fabian

AU - Grohmann, Andrea

AU - Dreger, Henryk

AU - Kmezik, Friederike

AU - Riemekasten, Gabriela

AU - Baumann, Gert

AU - Borges, Adrian C.

PY - 2010

Y1 - 2010

N2 - Background. Isovolumetric acceleration (IVA) is a novel tissue Doppler parameter for the assessment of systolic function. The aim of this study was to evaluate IVA as an early parameter for the detection of right ventricular (RV) systolic dysfunction in patients with systemic sclerosis (SSc) without pulmonary hypertension. Methods. 22 patients and 22 gender- and age-matched healthy subjects underwent standard echocardiography with tissue Doppler imaging (TDI) and speckle tracking strain to assess RV function. Results. Tricuspid annular plane systolic excursion (TAPSE) (23.2 ± 4.1 mm vs. 26.5 ± 2.9 mm, p < 0.006), peak myocardial systolic velocity (Sm) (11.6 ± 2.3 cm/s vs. 13.9 ± 2.7 cm/s, p = 0.005), isovolumetric contraction velocity (IVV) (10.3 3 cm/s vs. 14.8 3 cm/s, p < 0.001) and IVA (2.3 ± 0.4 m/s 2 vs. 4.1 ± 0.8 m/s2, p < 0.001) were significant lower in the patient group. IVA was the best parameter to predict early systolic dysfunction with an area under the curve of 0.988. Conclusion. IVA is a useful tool with high-predictive power to detect early right ventricular systolic impairment in patients with SSc and without pulmonary hypertension.

AB - Background. Isovolumetric acceleration (IVA) is a novel tissue Doppler parameter for the assessment of systolic function. The aim of this study was to evaluate IVA as an early parameter for the detection of right ventricular (RV) systolic dysfunction in patients with systemic sclerosis (SSc) without pulmonary hypertension. Methods. 22 patients and 22 gender- and age-matched healthy subjects underwent standard echocardiography with tissue Doppler imaging (TDI) and speckle tracking strain to assess RV function. Results. Tricuspid annular plane systolic excursion (TAPSE) (23.2 ± 4.1 mm vs. 26.5 ± 2.9 mm, p < 0.006), peak myocardial systolic velocity (Sm) (11.6 ± 2.3 cm/s vs. 13.9 ± 2.7 cm/s, p = 0.005), isovolumetric contraction velocity (IVV) (10.3 3 cm/s vs. 14.8 3 cm/s, p < 0.001) and IVA (2.3 ± 0.4 m/s 2 vs. 4.1 ± 0.8 m/s2, p < 0.001) were significant lower in the patient group. IVA was the best parameter to predict early systolic dysfunction with an area under the curve of 0.988. Conclusion. IVA is a useful tool with high-predictive power to detect early right ventricular systolic impairment in patients with SSc and without pulmonary hypertension.

UR - https://www.scopus.com/pages/publications/77149129285

U2 - 10.1186/1476-7120-8-3

DO - 10.1186/1476-7120-8-3

M3 - Journal articles

C2 - 20096122

AN - SCOPUS:77149129285

SN - 1476-7120

VL - 8

JO - Cardiovascular Ultrasound

JF - Cardiovascular Ultrasound

IS - 1

M1 - 3

ER -

Early right ventricular systolic dysfunction in patients with systemic sclerosis without pulmonary hypertension: A Doppler Tissue and Speckle Tracking echocardiography study

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