TY - JOUR
T1 - Early right ventricular systolic dysfunction in patients with systemic sclerosis without pulmonary hypertension: A Doppler Tissue and Speckle Tracking echocardiography study
AU - Schattke, Sebastian
AU - Knebel, Fabian
AU - Grohmann, Andrea
AU - Dreger, Henryk
AU - Kmezik, Friederike
AU - Riemekasten, Gabriela
AU - Baumann, Gert
AU - Borges, Adrian C.
N1 - Copyright:
Copyright 2010 Elsevier B.V., All rights reserved.
PY - 2010
Y1 - 2010
N2 - Background. Isovolumetric acceleration (IVA) is a novel tissue Doppler parameter for the assessment of systolic function. The aim of this study was to evaluate IVA as an early parameter for the detection of right ventricular (RV) systolic dysfunction in patients with systemic sclerosis (SSc) without pulmonary hypertension. Methods. 22 patients and 22 gender- and age-matched healthy subjects underwent standard echocardiography with tissue Doppler imaging (TDI) and speckle tracking strain to assess RV function. Results. Tricuspid annular plane systolic excursion (TAPSE) (23.2 ± 4.1 mm vs. 26.5 ± 2.9 mm, p < 0.006), peak myocardial systolic velocity (Sm) (11.6 ± 2.3 cm/s vs. 13.9 ± 2.7 cm/s, p = 0.005), isovolumetric contraction velocity (IVV) (10.3 3 cm/s vs. 14.8 3 cm/s, p < 0.001) and IVA (2.3 ± 0.4 m/s 2 vs. 4.1 ± 0.8 m/s2, p < 0.001) were significant lower in the patient group. IVA was the best parameter to predict early systolic dysfunction with an area under the curve of 0.988. Conclusion. IVA is a useful tool with high-predictive power to detect early right ventricular systolic impairment in patients with SSc and without pulmonary hypertension.
AB - Background. Isovolumetric acceleration (IVA) is a novel tissue Doppler parameter for the assessment of systolic function. The aim of this study was to evaluate IVA as an early parameter for the detection of right ventricular (RV) systolic dysfunction in patients with systemic sclerosis (SSc) without pulmonary hypertension. Methods. 22 patients and 22 gender- and age-matched healthy subjects underwent standard echocardiography with tissue Doppler imaging (TDI) and speckle tracking strain to assess RV function. Results. Tricuspid annular plane systolic excursion (TAPSE) (23.2 ± 4.1 mm vs. 26.5 ± 2.9 mm, p < 0.006), peak myocardial systolic velocity (Sm) (11.6 ± 2.3 cm/s vs. 13.9 ± 2.7 cm/s, p = 0.005), isovolumetric contraction velocity (IVV) (10.3 3 cm/s vs. 14.8 3 cm/s, p < 0.001) and IVA (2.3 ± 0.4 m/s 2 vs. 4.1 ± 0.8 m/s2, p < 0.001) were significant lower in the patient group. IVA was the best parameter to predict early systolic dysfunction with an area under the curve of 0.988. Conclusion. IVA is a useful tool with high-predictive power to detect early right ventricular systolic impairment in patients with SSc and without pulmonary hypertension.
UR - http://www.scopus.com/inward/record.url?scp=77149129285&partnerID=8YFLogxK
U2 - 10.1186/1476-7120-8-3
DO - 10.1186/1476-7120-8-3
M3 - Journal articles
C2 - 20096122
AN - SCOPUS:77149129285
SN - 1476-7120
VL - 8
JO - Cardiovascular Ultrasound
JF - Cardiovascular Ultrasound
IS - 1
M1 - 3
ER -
