Early effects of intravitreal triamcinolone acetonide on inflammation and proliferation in human choroidal neovascularization

Olcay Tatar, Annemarie Adam, Kei Shinoda, Edwin Kaiserling, Vicky Boeyden, Carl Claes, Claus Eckardt, Tillmann Eckert, Grazia Pertile, Gabor B. Scharioth, Efdal Yoeruek, Peter Szurman, Karl Ulrich Bartz-Schmidt, Salvatore Grisanti*

*Corresponding author for this work
8 Citations (Scopus)


Objective: To evaluate the early effects of triamcinolone acetonide (TA) on inflammation, proliferation, and vascular endothelial growth factor (VEGF) in human choroidal neovascularization (CNV). Methods: Retrospective review of an interventional case series of 29 patients who underwent macular translocation. Fourteen CNV membranes without previous therapy (control CNV group) and 4 CNV membranes excised 3 days after photodynamic therapy (PDT CNV group) comprised the control groups. Eleven patients were treated with intravitreal TA (TA CNV group; n=5) or PDT and TA combined (PDT+TA CNV group; n=6) 3 to 9 days preoperatively. The CNV membranes were stained for cytokeratin 18, CD34, VEGF, intercellular adhesion molecule-1 (ICAM-1), E-selectin, CD68, CD45, Ki-67, and Thy-1. Results: Treatment with TA and PDT+TA resulted in increased immunostaining of ICAM-1 in endothelial cells and the stroma and a higher percentage of Thy-1 expression than controls. The density of macrophages was significantly increased in PDT+TA CNV membranes. Leukocyte density and proliferative activity were lower in TA and PDT+TA CNV membranes. The total VEGF score was significantly increased in TA and PDT+TA CNV membranes compared with the control CNV membranes. Evidence of VEGF in the retinal pigment epithelium of PDT+TA CNV membranes was stronger than in control CNV membranes. Conclusions: Triamcinolone acetonide has no inhibitory effect on macrophage infiltration or ICAM-1, Thy-1, or VEGF expression in CNV membranes in the early term. The clinical benefits of TA are probably not based on pure antiinflammatory or VEGF-suppressing mechanisms.

Translated title of the contributionFrühe Auswirkungen von intravitrealem Triamcinolonacetonid auf Entzündung und Proliferation bei der menschlichen choroidalen Neovaskularisation
Original languageEnglish
JournalArchives of Ophthalmology
Issue number3
Pages (from-to)275-281
Number of pages7
Publication statusPublished - 01.03.2009


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