TY - JOUR
T1 - Dysregulation of MicroRNAs in angioimmunoblastic T-cell lymphoma
AU - Reddemann, Katharina
AU - Gola, Damian
AU - Schillert, Arne
AU - Knief, Juliana
AU - Kuempers, Christiane
AU - Ribbat-Idel, Julika
AU - Ber, Svetlana
AU - Schemme, Janina
AU - Bernard, Veronica
AU - Gebauer, Niklas
AU - Feller, Alfred Christian
AU - Thorns, Christoph
PY - 2015/1/1
Y1 - 2015/1/1
N2 - Background: Angioimmunoblastic T-cell lymphomas (AITLs) are the second most frequent peripheral T-cell lymphomas in humans worldwide and histomorphologically well characterized. MicroRNAs are a group of small noncoding RNAs that can negatively regulate gene expression on a posttranscriptional level. Their dysregulation has been shown to be of importance in numerous tumour entities. Materials and Methods: As a first step towards under standing the possible influence of microRNA-dysregulation in AITL, we analyzed the expression signatures of 760 microRNAs in 30 nodal AITLs in comparison to reactive lymphadenitis with T-zone hyperplasia. Results: We found miR-34a, miR-146a and miR-193b to be upregulated, as well as miR-140-3p, let-7g, miR-30b and miR-664 to be down-regulated in AITL to a significant level. Conclusion: The microRNA-signatures of AITL reveal some overlap to autoimmune diseases, virus-triggered lymphomas and angiogenic factors that, coupled with future studies, will potentially provide better understanding of this disease.
AB - Background: Angioimmunoblastic T-cell lymphomas (AITLs) are the second most frequent peripheral T-cell lymphomas in humans worldwide and histomorphologically well characterized. MicroRNAs are a group of small noncoding RNAs that can negatively regulate gene expression on a posttranscriptional level. Their dysregulation has been shown to be of importance in numerous tumour entities. Materials and Methods: As a first step towards under standing the possible influence of microRNA-dysregulation in AITL, we analyzed the expression signatures of 760 microRNAs in 30 nodal AITLs in comparison to reactive lymphadenitis with T-zone hyperplasia. Results: We found miR-34a, miR-146a and miR-193b to be upregulated, as well as miR-140-3p, let-7g, miR-30b and miR-664 to be down-regulated in AITL to a significant level. Conclusion: The microRNA-signatures of AITL reveal some overlap to autoimmune diseases, virus-triggered lymphomas and angiogenic factors that, coupled with future studies, will potentially provide better understanding of this disease.
UR - http://www.scopus.com/inward/record.url?scp=84928379233&partnerID=8YFLogxK
M3 - Journal articles
C2 - 25862860
AN - SCOPUS:84928379233
SN - 0250-7005
VL - 35
SP - 2055
EP - 2061
JO - Anticancer Research
JF - Anticancer Research
IS - 4
ER -
