Dysregulation of MicroRNAs in angioimmunoblastic T-cell lymphoma

Katharina Reddemann*, Damian Gola, Arne Schillert, Juliana Knief, Christiane Kuempers, Julika Ribbat-Idel, Svetlana Ber, Janina Schemme, Veronica Bernard, Niklas Gebauer, Alfred Christian Feller, Christoph Thorns

*Corresponding author for this work
6 Citations (Scopus)


Background: Angioimmunoblastic T-cell lymphomas (AITLs) are the second most frequent peripheral T-cell lymphomas in humans worldwide and histomorphologically well characterized. MicroRNAs are a group of small noncoding RNAs that can negatively regulate gene expression on a posttranscriptional level. Their dysregulation has been shown to be of importance in numerous tumour entities. Materials and Methods: As a first step towards under standing the possible influence of microRNA-dysregulation in AITL, we analyzed the expression signatures of 760 microRNAs in 30 nodal AITLs in comparison to reactive lymphadenitis with T-zone hyperplasia. Results: We found miR-34a, miR-146a and miR-193b to be upregulated, as well as miR-140-3p, let-7g, miR-30b and miR-664 to be down-regulated in AITL to a significant level. Conclusion: The microRNA-signatures of AITL reveal some overlap to autoimmune diseases, virus-triggered lymphomas and angiogenic factors that, coupled with future studies, will potentially provide better understanding of this disease.

Original languageEnglish
JournalAnticancer Research
Issue number4
Pages (from-to)2055-2061
Number of pages7
Publication statusPublished - 01.01.2015


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