TY - JOUR
T1 - Drug safety and adverse drug reaction reporting behavior related to outpatient opioid replacement therapy: Results from a survey among physicians
AU - Gahr, Maximilian
AU - Eller, Jonas
AU - Cabanis, Maurice
AU - Hiemke, Christoph
AU - Freudenmann, Roland W.
AU - Connemann, Bernhard J.
AU - Lang, Dirk
AU - Schönfeldt-Lecuona, Carlos
PY - 2017/3/1
Y1 - 2017/3/1
N2 - To study drug safety and the reporting behavior of adverse drug reactions (ADR) related to agents used for opioid replacement therapy (ORT) we conducted a cross-sectional questionnaire-based telephone survey among physicians who provide outpatient ORT in Germany (n = 176; response rate = 55.7%). Most respondents (n = 97/55.1%) reported that they observe ADR related to buprenorphine, (dihydro)codeine, and (levo)methdone rarely (n = 38/21.6%), very rarely (n = 39/22.2%) or never (n = 20/11.4%). Methadone was reported to be most frequently associated with the occurrence of ADR (n = 82/46.6%), followed by levomethadone (n = 33/18.8%), buprenorphine (n = 6/3.4%), and dihydrocodeine (n = 3/1.7%). Frequently observed ADR related to these agents were gastrointestinal, nervous system/psychiatric disorders, and hyperhidrosis. Methadone and levomethadone (not buprenorphine) were frequently associated with fatigue, weight gain, and sexual dysfunction. Hundred twenty nine participants (73.3%) stated that they never report ADR related to ORT; n = 19 (10.8%) did so when referring to ADR related to their complete medical practice (X2 = 141.070; df = 1; p < 0.001). Similar patterns of ADR related to outpatient ORT as those reported in the product information or in pain therapy were found. Motivation to report ADR related to ORT may be reduced compared to ADR related to the general medical practice.
AB - To study drug safety and the reporting behavior of adverse drug reactions (ADR) related to agents used for opioid replacement therapy (ORT) we conducted a cross-sectional questionnaire-based telephone survey among physicians who provide outpatient ORT in Germany (n = 176; response rate = 55.7%). Most respondents (n = 97/55.1%) reported that they observe ADR related to buprenorphine, (dihydro)codeine, and (levo)methdone rarely (n = 38/21.6%), very rarely (n = 39/22.2%) or never (n = 20/11.4%). Methadone was reported to be most frequently associated with the occurrence of ADR (n = 82/46.6%), followed by levomethadone (n = 33/18.8%), buprenorphine (n = 6/3.4%), and dihydrocodeine (n = 3/1.7%). Frequently observed ADR related to these agents were gastrointestinal, nervous system/psychiatric disorders, and hyperhidrosis. Methadone and levomethadone (not buprenorphine) were frequently associated with fatigue, weight gain, and sexual dysfunction. Hundred twenty nine participants (73.3%) stated that they never report ADR related to ORT; n = 19 (10.8%) did so when referring to ADR related to their complete medical practice (X2 = 141.070; df = 1; p < 0.001). Similar patterns of ADR related to outpatient ORT as those reported in the product information or in pain therapy were found. Motivation to report ADR related to ORT may be reduced compared to ADR related to the general medical practice.
UR - http://www.scopus.com/inward/record.url?scp=85006506875&partnerID=8YFLogxK
U2 - 10.1016/j.jsat.2016.12.002
DO - 10.1016/j.jsat.2016.12.002
M3 - Journal articles
C2 - 28132703
AN - SCOPUS:85006506875
SN - 0740-5472
VL - 74
SP - 7
EP - 15
JO - Journal of Substance Abuse Treatment
JF - Journal of Substance Abuse Treatment
ER -
