Down syndrome and male fertility: PCR‐derived fingerprinting, serological and andrological investigations

Christine Zühlke; Ulrike Thies; Ingrid Braulke; André Reis; Carl Schirren

doi:10.1111/j.1399-0004.1994.tb04171.x

Down syndrome and male fertility: PCR‐derived fingerprinting, serological and andrological investigations

Christine Zühlke^*, Ulrike Thies, Ingrid Braulke, André Reis, Carl Schirren

^*Corresponding author for this work

Institute of Human Genetics

41 Citations (Scopus)

Abstract

Down syndrome, the most common birth defect causing mental retardation, is characterized by a specific phenotype including subfertility or sterility and hypogonadism in males. In contrast, several females with Down syndrome have borne offspring. Here, a male with trisomy 21 fathering an infant is described. This observation is verified by serological markers, DNA fingerprinting using different DNA micro‐or minisatellites and andrological investigations.

Original language	English
Journal	Clinical Genetics
Volume	46
Issue number	4
Pages (from-to)	324-326
Number of pages	3
ISSN	0009-9163
DOIs	https://doi.org/10.1111/j.1399-0004.1994.tb04171.x
Publication status	Published - 10.1994

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This output contributes to the following UN Sustainable Development Goals (SDGs)

SDG 3 Good Health and Well-being

Research Areas and Centers

Research Area: Medical Genetics

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10.1111/j.1399-0004.1994.tb04171.x

Cite this

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abstract = "Down syndrome, the most common birth defect causing mental retardation, is characterized by a specific phenotype including subfertility or sterility and hypogonadism in males. In contrast, several females with Down syndrome have borne offspring. Here, a male with trisomy 21 fathering an infant is described. This observation is verified by serological markers, DNA fingerprinting using different DNA micro‐or minisatellites and andrological investigations.",

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AU - Zühlke, Christine

AU - Thies, Ulrike

AU - Braulke, Ingrid

AU - Reis, André

AU - Schirren, Carl

PY - 1994/10

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AB - Down syndrome, the most common birth defect causing mental retardation, is characterized by a specific phenotype including subfertility or sterility and hypogonadism in males. In contrast, several females with Down syndrome have borne offspring. Here, a male with trisomy 21 fathering an infant is described. This observation is verified by serological markers, DNA fingerprinting using different DNA micro‐or minisatellites and andrological investigations.

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M3 - Journal articles

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Down syndrome and male fertility: PCR‐derived fingerprinting, serological and andrological investigations

Abstract

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