Dose-response relation between volume of drinking and alcohol-related diseases in male general hospital inpatients

Katharina Lau; Jennis Freyer-adam; Beate Coder; Jeannette Riedel; Hans Jürgen Rumpf; Ulrich John; Ulfert Hapke

doi:10.1093/alcalc/agm154

Dose-response relation between volume of drinking and alcohol-related diseases in male general hospital inpatients

Katharina Lau^*, Jennis Freyer-adam, Beate Coder, Jeannette Riedel, Hans Jürgen Rumpf, Ulrich John, Ulfert Hapke

^*Corresponding author for this work

Department of Psychiatry, Psychosomatics and Psychotherapie

University of Greifswald

22 Citations (Scopus)

Abstract

Aims: Previous studies investigating dose-response relations between volume of drinking and diseases have focused on single diseases only. Until now, the relation between the drinking volume and the risk of having any alcohol-attributable disease is largely unknown. The aim of the present study is to investigate to what extent is the risk of diseases with different alcohol-attributable fractions (AAFs) predicted by daily alcohol consumption (> 120 g, 61 - 120 g vs 31 - 60 g). Methods: The sample consisted of 805 inpatients classified as at-risk drinking, aged 18 - 64 years hailing from four general hospitals in North-eastern Germany. Inpatients were classified into three groups (AAF = 1, AAF < 1, AAF = 0). Group differences regarding alcohol-related variables, smoking, and demographics were analysed. A multinomial logistic regression analysis was conducted to predict the risk of diseases with AAF = 1 and AAF < 1. Results: In our sample, 26.6% of the inpatients showed a disease with AAF = 1, while 20.2% had a disease with AAF < 1. Inpatients consuming > 120 g, and inpatients consuming 61 - 120 g revealed significantly higher odds for diseases with AAF = 1 compared to inpatients consuming 31 - 60 g (OR = 6.30, CI = 3.55 - 11.26; OR = 2.91, CI = 1.64 - 5.13). Regarding diseases with AAF = 1, inpatients consuming > 120 g revealed significantly higher odds compared to the inpatients consuming 31 - 60 g (OR = 1.97, CI = 1.15 - 3.37). Conclusion: A dose-response relation between the level of the drinking volume and the risk of diseases with AAF = 1 was found in this sample of inpatients from the general hospitals.

Original language	English
Journal	Alcohol and Alcoholism
Volume	43
Issue number	1
Pages (from-to)	34-38
Number of pages	5
ISSN	0735-0414
DOIs	https://doi.org/10.1093/alcalc/agm154
Publication status	Published - 01.2008

Funding

Acknowledgements — This study, as part of the Research Collaboration in Early substance use Intervention (EARLINT), has been funded by the German Federal Ministry of Education and Research (01EB0120, 01EB0420) and the Social Ministry of the State of Mecklenburg-Western Pomerania (IX 311a 406.68.43.05).

UN SDGs

This output contributes to the following UN Sustainable Development Goals (SDGs)

SDG 3 Good Health and Well-being
SDG 10 Reduced Inequalities

Research Areas and Centers

Academic Focus: Center for Brain, Behavior and Metabolism (CBBM)

Access to Document

10.1093/alcalc/agm154

Cite this

@article{339f39c1620b47968cd52ebeadb2bce9,

title = "Dose-response relation between volume of drinking and alcohol-related diseases in male general hospital inpatients",

abstract = "Aims: Previous studies investigating dose-response relations between volume of drinking and diseases have focused on single diseases only. Until now, the relation between the drinking volume and the risk of having any alcohol-attributable disease is largely unknown. The aim of the present study is to investigate to what extent is the risk of diseases with different alcohol-attributable fractions (AAFs) predicted by daily alcohol consumption (> 120 g, 61 - 120 g vs 31 - 60 g). Methods: The sample consisted of 805 inpatients classified as at-risk drinking, aged 18 - 64 years hailing from four general hospitals in North-eastern Germany. Inpatients were classified into three groups (AAF = 1, AAF < 1, AAF = 0). Group differences regarding alcohol-related variables, smoking, and demographics were analysed. A multinomial logistic regression analysis was conducted to predict the risk of diseases with AAF = 1 and AAF < 1. Results: In our sample, 26.6\% of the inpatients showed a disease with AAF = 1, while 20.2\% had a disease with AAF < 1. Inpatients consuming > 120 g, and inpatients consuming 61 - 120 g revealed significantly higher odds for diseases with AAF = 1 compared to inpatients consuming 31 - 60 g (OR = 6.30, CI = 3.55 - 11.26; OR = 2.91, CI = 1.64 - 5.13). Regarding diseases with AAF = 1, inpatients consuming > 120 g revealed significantly higher odds compared to the inpatients consuming 31 - 60 g (OR = 1.97, CI = 1.15 - 3.37). Conclusion: A dose-response relation between the level of the drinking volume and the risk of diseases with AAF = 1 was found in this sample of inpatients from the general hospitals.",

author = "Katharina Lau and Jennis Freyer-adam and Beate Coder and Jeannette Riedel and Rumpf, \{Hans J{\"u}rgen\} and Ulrich John and Ulfert Hapke",

note = "Funding Information: Acknowledgements — This study, as part of the Research Collaboration in Early substance use Intervention (EARLINT), has been funded by the German Federal Ministry of Education and Research (01EB0120, 01EB0420) and the Social Ministry of the State of Mecklenburg-Western Pomerania (IX 311a 406.68.43.05). Copyright: Copyright 2008 Elsevier B.V., All rights reserved.",

year = "2008",

month = jan,

doi = "10.1093/alcalc/agm154",

language = "English",

volume = "43",

pages = "34--38",

journal = "Alcohol and Alcoholism",

issn = "0735-0414",

publisher = "Oxford University Press",

number = "1",

}

TY - JOUR

T1 - Dose-response relation between volume of drinking and alcohol-related diseases in male general hospital inpatients

AU - Lau, Katharina

AU - Freyer-adam, Jennis

AU - Coder, Beate

AU - Riedel, Jeannette

AU - Rumpf, Hans Jürgen

AU - John, Ulrich

AU - Hapke, Ulfert

N1 - Funding Information: Acknowledgements — This study, as part of the Research Collaboration in Early substance use Intervention (EARLINT), has been funded by the German Federal Ministry of Education and Research (01EB0120, 01EB0420) and the Social Ministry of the State of Mecklenburg-Western Pomerania (IX 311a 406.68.43.05). Copyright: Copyright 2008 Elsevier B.V., All rights reserved.

PY - 2008/1

Y1 - 2008/1

N2 - Aims: Previous studies investigating dose-response relations between volume of drinking and diseases have focused on single diseases only. Until now, the relation between the drinking volume and the risk of having any alcohol-attributable disease is largely unknown. The aim of the present study is to investigate to what extent is the risk of diseases with different alcohol-attributable fractions (AAFs) predicted by daily alcohol consumption (> 120 g, 61 - 120 g vs 31 - 60 g). Methods: The sample consisted of 805 inpatients classified as at-risk drinking, aged 18 - 64 years hailing from four general hospitals in North-eastern Germany. Inpatients were classified into three groups (AAF = 1, AAF < 1, AAF = 0). Group differences regarding alcohol-related variables, smoking, and demographics were analysed. A multinomial logistic regression analysis was conducted to predict the risk of diseases with AAF = 1 and AAF < 1. Results: In our sample, 26.6% of the inpatients showed a disease with AAF = 1, while 20.2% had a disease with AAF < 1. Inpatients consuming > 120 g, and inpatients consuming 61 - 120 g revealed significantly higher odds for diseases with AAF = 1 compared to inpatients consuming 31 - 60 g (OR = 6.30, CI = 3.55 - 11.26; OR = 2.91, CI = 1.64 - 5.13). Regarding diseases with AAF = 1, inpatients consuming > 120 g revealed significantly higher odds compared to the inpatients consuming 31 - 60 g (OR = 1.97, CI = 1.15 - 3.37). Conclusion: A dose-response relation between the level of the drinking volume and the risk of diseases with AAF = 1 was found in this sample of inpatients from the general hospitals.

AB - Aims: Previous studies investigating dose-response relations between volume of drinking and diseases have focused on single diseases only. Until now, the relation between the drinking volume and the risk of having any alcohol-attributable disease is largely unknown. The aim of the present study is to investigate to what extent is the risk of diseases with different alcohol-attributable fractions (AAFs) predicted by daily alcohol consumption (> 120 g, 61 - 120 g vs 31 - 60 g). Methods: The sample consisted of 805 inpatients classified as at-risk drinking, aged 18 - 64 years hailing from four general hospitals in North-eastern Germany. Inpatients were classified into three groups (AAF = 1, AAF < 1, AAF = 0). Group differences regarding alcohol-related variables, smoking, and demographics were analysed. A multinomial logistic regression analysis was conducted to predict the risk of diseases with AAF = 1 and AAF < 1. Results: In our sample, 26.6% of the inpatients showed a disease with AAF = 1, while 20.2% had a disease with AAF < 1. Inpatients consuming > 120 g, and inpatients consuming 61 - 120 g revealed significantly higher odds for diseases with AAF = 1 compared to inpatients consuming 31 - 60 g (OR = 6.30, CI = 3.55 - 11.26; OR = 2.91, CI = 1.64 - 5.13). Regarding diseases with AAF = 1, inpatients consuming > 120 g revealed significantly higher odds compared to the inpatients consuming 31 - 60 g (OR = 1.97, CI = 1.15 - 3.37). Conclusion: A dose-response relation between the level of the drinking volume and the risk of diseases with AAF = 1 was found in this sample of inpatients from the general hospitals.

UR - https://www.scopus.com/pages/publications/37749045616

U2 - 10.1093/alcalc/agm154

DO - 10.1093/alcalc/agm154

M3 - Journal articles

C2 - 18039675

AN - SCOPUS:37749045616

SN - 0735-0414

VL - 43

SP - 34

EP - 38

JO - Alcohol and Alcoholism

JF - Alcohol and Alcoholism

IS - 1

ER -

Dose-response relation between volume of drinking and alcohol-related diseases in male general hospital inpatients

Abstract

Funding

UN SDGs

Research Areas and Centers

Access to Document

Other files and links

Fingerprint

Cite this