TY - JOUR
T1 - Dose-response relation between volume of drinking and alcohol-related diseases in male general hospital inpatients
AU - Lau, Katharina
AU - Freyer-adam, Jennis
AU - Coder, Beate
AU - Riedel, Jeannette
AU - Rumpf, Hans Jürgen
AU - John, Ulrich
AU - Hapke, Ulfert
N1 - Funding Information:
Acknowledgements — This study, as part of the Research Collaboration in Early substance use Intervention (EARLINT), has been funded by the German Federal Ministry of Education and Research (01EB0120, 01EB0420) and the Social Ministry of the State of Mecklenburg-Western Pomerania (IX 311a 406.68.43.05).
Copyright:
Copyright 2008 Elsevier B.V., All rights reserved.
PY - 2008/1
Y1 - 2008/1
N2 - Aims: Previous studies investigating dose-response relations between volume of drinking and diseases have focused on single diseases only. Until now, the relation between the drinking volume and the risk of having any alcohol-attributable disease is largely unknown. The aim of the present study is to investigate to what extent is the risk of diseases with different alcohol-attributable fractions (AAFs) predicted by daily alcohol consumption (> 120 g, 61 - 120 g vs 31 - 60 g). Methods: The sample consisted of 805 inpatients classified as at-risk drinking, aged 18 - 64 years hailing from four general hospitals in North-eastern Germany. Inpatients were classified into three groups (AAF = 1, AAF < 1, AAF = 0). Group differences regarding alcohol-related variables, smoking, and demographics were analysed. A multinomial logistic regression analysis was conducted to predict the risk of diseases with AAF = 1 and AAF < 1. Results: In our sample, 26.6% of the inpatients showed a disease with AAF = 1, while 20.2% had a disease with AAF < 1. Inpatients consuming > 120 g, and inpatients consuming 61 - 120 g revealed significantly higher odds for diseases with AAF = 1 compared to inpatients consuming 31 - 60 g (OR = 6.30, CI = 3.55 - 11.26; OR = 2.91, CI = 1.64 - 5.13). Regarding diseases with AAF = 1, inpatients consuming > 120 g revealed significantly higher odds compared to the inpatients consuming 31 - 60 g (OR = 1.97, CI = 1.15 - 3.37). Conclusion: A dose-response relation between the level of the drinking volume and the risk of diseases with AAF = 1 was found in this sample of inpatients from the general hospitals.
AB - Aims: Previous studies investigating dose-response relations between volume of drinking and diseases have focused on single diseases only. Until now, the relation between the drinking volume and the risk of having any alcohol-attributable disease is largely unknown. The aim of the present study is to investigate to what extent is the risk of diseases with different alcohol-attributable fractions (AAFs) predicted by daily alcohol consumption (> 120 g, 61 - 120 g vs 31 - 60 g). Methods: The sample consisted of 805 inpatients classified as at-risk drinking, aged 18 - 64 years hailing from four general hospitals in North-eastern Germany. Inpatients were classified into three groups (AAF = 1, AAF < 1, AAF = 0). Group differences regarding alcohol-related variables, smoking, and demographics were analysed. A multinomial logistic regression analysis was conducted to predict the risk of diseases with AAF = 1 and AAF < 1. Results: In our sample, 26.6% of the inpatients showed a disease with AAF = 1, while 20.2% had a disease with AAF < 1. Inpatients consuming > 120 g, and inpatients consuming 61 - 120 g revealed significantly higher odds for diseases with AAF = 1 compared to inpatients consuming 31 - 60 g (OR = 6.30, CI = 3.55 - 11.26; OR = 2.91, CI = 1.64 - 5.13). Regarding diseases with AAF = 1, inpatients consuming > 120 g revealed significantly higher odds compared to the inpatients consuming 31 - 60 g (OR = 1.97, CI = 1.15 - 3.37). Conclusion: A dose-response relation between the level of the drinking volume and the risk of diseases with AAF = 1 was found in this sample of inpatients from the general hospitals.
UR - http://www.scopus.com/inward/record.url?scp=37749045616&partnerID=8YFLogxK
U2 - 10.1093/alcalc/agm154
DO - 10.1093/alcalc/agm154
M3 - Journal articles
C2 - 18039675
AN - SCOPUS:37749045616
SN - 0735-0414
VL - 43
SP - 34
EP - 38
JO - Alcohol and Alcoholism
JF - Alcohol and Alcoholism
IS - 1
ER -
