Dopamine transmission in DYT1 dystonia: A biochemical and autoradiographical study

S. J. Augood; Z. Hollingsworth; D. S. Albers; L. Yang; J. C. Leung; B. Muller; C. Klein; X. O. Breakefield; D. G. Standaert

doi:10.1212/WNL.59.3.445

Dopamine transmission in DYT1 dystonia: A biochemical and autoradiographical study

S. J. Augood^*
, Z. Hollingsworth
, D. S. Albers
, L. Yang
, J. C. Leung
, B. Muller
, C. Klein
, X. O. Breakefield
, D. G. Standaert

^*Corresponding author for this work

Institute of Neurogenetics

Harvard University
Center for Aging
Department of Neurology and Neurosciences
Weill Cornell Medical College

121 Citations (Scopus)

Abstract

Indices of dopamine transmission were measured in the postmortem striatum of DYT1 dystonia brains. A significant increase in the striatal 3,4-dihydroxyphenylacetic acid/dopamine ratio was found. Quantitative autoradiography revealed no differences in the density of dopamine transporter or vesicular monoamine transporter-2 binding; however, there was a trend toward a reduction in D₁, receptor and D₂ receptor binding. One brain with DYT1 parkinsonism was similarly evaluated and marked reductions in striatal dopamine, 3,4-dihydroxyphenylacetic acid, and homovanillic acid content as well as the density of binding of all four dopaminergic ligands were measured.

Original language	English
Journal	Neurology
Volume	59
Issue number	3
Pages (from-to)	445-448
Number of pages	4
ISSN	0028-3878
DOIs	https://doi.org/10.1212/WNL.59.3.445
Publication status	Published - 13.08.2002

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title = "Dopamine transmission in DYT1 dystonia: A biochemical and autoradiographical study",

abstract = "Indices of dopamine transmission were measured in the postmortem striatum of DYT1 dystonia brains. A significant increase in the striatal 3,4-dihydroxyphenylacetic acid/dopamine ratio was found. Quantitative autoradiography revealed no differences in the density of dopamine transporter or vesicular monoamine transporter-2 binding; however, there was a trend toward a reduction in D1, receptor and D2 receptor binding. One brain with DYT1 parkinsonism was similarly evaluated and marked reductions in striatal dopamine, 3,4-dihydroxyphenylacetic acid, and homovanillic acid content as well as the density of binding of all four dopaminergic ligands were measured.",

author = "Augood, \{S. J.\} and Z. Hollingsworth and Albers, \{D. S.\} and L. Yang and Leung, \{J. C.\} and B. Muller and C. Klein and Breakefield, \{X. O.\} and Standaert, \{D. G.\}",

year = "2002",

month = aug,

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doi = "10.1212/WNL.59.3.445",

language = "English",

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T1 - Dopamine transmission in DYT1 dystonia: A biochemical and autoradiographical study

AU - Augood, S. J.

AU - Hollingsworth, Z.

AU - Albers, D. S.

AU - Yang, L.

AU - Leung, J. C.

AU - Muller, B.

AU - Klein, C.

AU - Breakefield, X. O.

AU - Standaert, D. G.

PY - 2002/8/13

Y1 - 2002/8/13

N2 - Indices of dopamine transmission were measured in the postmortem striatum of DYT1 dystonia brains. A significant increase in the striatal 3,4-dihydroxyphenylacetic acid/dopamine ratio was found. Quantitative autoradiography revealed no differences in the density of dopamine transporter or vesicular monoamine transporter-2 binding; however, there was a trend toward a reduction in D1, receptor and D2 receptor binding. One brain with DYT1 parkinsonism was similarly evaluated and marked reductions in striatal dopamine, 3,4-dihydroxyphenylacetic acid, and homovanillic acid content as well as the density of binding of all four dopaminergic ligands were measured.

AB - Indices of dopamine transmission were measured in the postmortem striatum of DYT1 dystonia brains. A significant increase in the striatal 3,4-dihydroxyphenylacetic acid/dopamine ratio was found. Quantitative autoradiography revealed no differences in the density of dopamine transporter or vesicular monoamine transporter-2 binding; however, there was a trend toward a reduction in D1, receptor and D2 receptor binding. One brain with DYT1 parkinsonism was similarly evaluated and marked reductions in striatal dopamine, 3,4-dihydroxyphenylacetic acid, and homovanillic acid content as well as the density of binding of all four dopaminergic ligands were measured.

UR - https://www.scopus.com/pages/publications/0037072281

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DO - 10.1212/WNL.59.3.445

M3 - Journal articles

AN - SCOPUS:0037072281

SN - 0028-3878

VL - 59

SP - 445

EP - 448

JO - Neurology

JF - Neurology

IS - 3

ER -

Dopamine transmission in DYT1 dystonia: A biochemical and autoradiographical study

Abstract

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