Dopamine transmission in DYT1 dystonia: A biochemical and autoradiographical study

S. J. Augood; Z. Hollingsworth; D. S. Albers; L. Yang; J. C. Leung; B. Muller; C. Klein; X. O. Breakefield; D. G. Standaert

doi:10.1212/WNL.59.3.445

Dopamine transmission in DYT1 dystonia: A biochemical and autoradiographical study

S. J. Augood^*, Z. Hollingsworth, D. S. Albers, L. Yang, J. C. Leung, B. Muller, C. Klein, X. O. Breakefield, D. G. Standaert

^*Corresponding author for this work

Institute of Neurogenetics

88 Citations (Scopus)

Abstract

Indices of dopamine transmission were measured in the postmortem striatum of DYT1 dystonia brains. A significant increase in the striatal 3,4-dihydroxyphenylacetic acid/dopamine ratio was found. Quantitative autoradiography revealed no differences in the density of dopamine transporter or vesicular monoamine transporter-2 binding; however, there was a trend toward a reduction in D₁, receptor and D₂ receptor binding. One brain with DYT1 parkinsonism was similarly evaluated and marked reductions in striatal dopamine, 3,4-dihydroxyphenylacetic acid, and homovanillic acid content as well as the density of binding of all four dopaminergic ligands were measured.

Original language	English
Journal	Neurology
Volume	59
Issue number	3
Pages (from-to)	445-448
Number of pages	4
ISSN	0028-3878
DOIs	https://doi.org/10.1212/WNL.59.3.445
Publication status	Published - 13.08.2002

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title = "Dopamine transmission in DYT1 dystonia: A biochemical and autoradiographical study",

abstract = "Indices of dopamine transmission were measured in the postmortem striatum of DYT1 dystonia brains. A significant increase in the striatal 3,4-dihydroxyphenylacetic acid/dopamine ratio was found. Quantitative autoradiography revealed no differences in the density of dopamine transporter or vesicular monoamine transporter-2 binding; however, there was a trend toward a reduction in D1, receptor and D2 receptor binding. One brain with DYT1 parkinsonism was similarly evaluated and marked reductions in striatal dopamine, 3,4-dihydroxyphenylacetic acid, and homovanillic acid content as well as the density of binding of all four dopaminergic ligands were measured.",

author = "Augood, {S. J.} and Z. Hollingsworth and Albers, {D. S.} and L. Yang and Leung, {J. C.} and B. Muller and C. Klein and Breakefield, {X. O.} and Standaert, {D. G.}",

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T1 - Dopamine transmission in DYT1 dystonia: A biochemical and autoradiographical study

AU - Augood, S. J.

AU - Hollingsworth, Z.

AU - Albers, D. S.

AU - Yang, L.

AU - Leung, J. C.

AU - Muller, B.

AU - Klein, C.

AU - Breakefield, X. O.

AU - Standaert, D. G.

PY - 2002/8/13

Y1 - 2002/8/13

N2 - Indices of dopamine transmission were measured in the postmortem striatum of DYT1 dystonia brains. A significant increase in the striatal 3,4-dihydroxyphenylacetic acid/dopamine ratio was found. Quantitative autoradiography revealed no differences in the density of dopamine transporter or vesicular monoamine transporter-2 binding; however, there was a trend toward a reduction in D1, receptor and D2 receptor binding. One brain with DYT1 parkinsonism was similarly evaluated and marked reductions in striatal dopamine, 3,4-dihydroxyphenylacetic acid, and homovanillic acid content as well as the density of binding of all four dopaminergic ligands were measured.

AB - Indices of dopamine transmission were measured in the postmortem striatum of DYT1 dystonia brains. A significant increase in the striatal 3,4-dihydroxyphenylacetic acid/dopamine ratio was found. Quantitative autoradiography revealed no differences in the density of dopamine transporter or vesicular monoamine transporter-2 binding; however, there was a trend toward a reduction in D1, receptor and D2 receptor binding. One brain with DYT1 parkinsonism was similarly evaluated and marked reductions in striatal dopamine, 3,4-dihydroxyphenylacetic acid, and homovanillic acid content as well as the density of binding of all four dopaminergic ligands were measured.

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DO - 10.1212/WNL.59.3.445

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SN - 0028-3878

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SP - 445

EP - 448

JO - Neurology

JF - Neurology

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Dopamine transmission in DYT1 dystonia: A biochemical and autoradiographical study

Abstract

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