Dopamine transmission in DYT1 dystonia: A biochemical and autoradiographical study

S. J. Augood*, Z. Hollingsworth, D. S. Albers, L. Yang, J. C. Leung, B. Muller, C. Klein, X. O. Breakefield, D. G. Standaert

*Corresponding author for this work
88 Citations (Scopus)


Indices of dopamine transmission were measured in the postmortem striatum of DYT1 dystonia brains. A significant increase in the striatal 3,4-dihydroxyphenylacetic acid/dopamine ratio was found. Quantitative autoradiography revealed no differences in the density of dopamine transporter or vesicular monoamine transporter-2 binding; however, there was a trend toward a reduction in D1, receptor and D2 receptor binding. One brain with DYT1 parkinsonism was similarly evaluated and marked reductions in striatal dopamine, 3,4-dihydroxyphenylacetic acid, and homovanillic acid content as well as the density of binding of all four dopaminergic ligands were measured.

Original languageEnglish
Issue number3
Pages (from-to)445-448
Number of pages4
Publication statusPublished - 13.08.2002


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