Abstract
Indices of dopamine transmission were measured in the postmortem striatum of DYT1 dystonia brains. A significant increase in the striatal 3,4-dihydroxyphenylacetic acid/dopamine ratio was found. Quantitative autoradiography revealed no differences in the density of dopamine transporter or vesicular monoamine transporter-2 binding; however, there was a trend toward a reduction in D1, receptor and D2 receptor binding. One brain with DYT1 parkinsonism was similarly evaluated and marked reductions in striatal dopamine, 3,4-dihydroxyphenylacetic acid, and homovanillic acid content as well as the density of binding of all four dopaminergic ligands were measured.
Original language | English |
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Journal | Neurology |
Volume | 59 |
Issue number | 3 |
Pages (from-to) | 445-448 |
Number of pages | 4 |
ISSN | 0028-3878 |
DOIs | |
Publication status | Published - 13.08.2002 |