TY - JOUR
T1 - Does Hippocampal Volume Predict Transition to Psychosis in a High-Risk Group? A Meta-Analysis
AU - Hinney, Bernd
AU - Walter, Anna
AU - Aghlmandi, Soheila
AU - Andreou, Christina
AU - Borgwardt, Stefan
N1 - Publisher Copyright:
© Copyright © 2021 Hinney, Walter, Aghlmandi, Andreou and Borgwardt.
PY - 2021/1/14
Y1 - 2021/1/14
N2 - Schizophrenia has a prodromal phase of several years in most patients, making it possible to identify patients at clinical high risk (CHR) for developing the disorder. So far, these individuals are identified based on clinical criteria alone, and there is no reliable biomarker for predicting the transition to psychosis. It is well-established that reductions in brain volume, especially in the hippocampus, are associated with schizophrenia. Therefore, hippocampal volume may serve as a biomarker for psychosis. Several studies have already investigated hippocampal volume in CHR groups. Based on these studies, the present meta-analysis compares the baseline left and right hippocampal volume of CHR patients who developed a psychosis with that of CHR patients without such a transition. Our results show no statistically significant effect of the hippocampal volume on the transition risk for psychosis.
AB - Schizophrenia has a prodromal phase of several years in most patients, making it possible to identify patients at clinical high risk (CHR) for developing the disorder. So far, these individuals are identified based on clinical criteria alone, and there is no reliable biomarker for predicting the transition to psychosis. It is well-established that reductions in brain volume, especially in the hippocampus, are associated with schizophrenia. Therefore, hippocampal volume may serve as a biomarker for psychosis. Several studies have already investigated hippocampal volume in CHR groups. Based on these studies, the present meta-analysis compares the baseline left and right hippocampal volume of CHR patients who developed a psychosis with that of CHR patients without such a transition. Our results show no statistically significant effect of the hippocampal volume on the transition risk for psychosis.
UR - http://www.scopus.com/inward/record.url?scp=85101958812&partnerID=8YFLogxK
U2 - 10.3389/fpsyt.2020.614659
DO - 10.3389/fpsyt.2020.614659
M3 - Scientific review articles
AN - SCOPUS:85101958812
SN - 1664-0640
VL - 11
JO - Frontiers in Psychiatry
JF - Frontiers in Psychiatry
M1 - 614659
ER -