Does Hippocampal Volume Predict Transition to Psychosis in a High-Risk Group? A Meta-Analysis

Bernd Hinney*, Anna Walter, Soheila Aghlmandi, Christina Andreou, Stefan Borgwardt

*Corresponding author for this work
1 Citation (Scopus)

Abstract

Schizophrenia has a prodromal phase of several years in most patients, making it possible to identify patients at clinical high risk (CHR) for developing the disorder. So far, these individuals are identified based on clinical criteria alone, and there is no reliable biomarker for predicting the transition to psychosis. It is well-established that reductions in brain volume, especially in the hippocampus, are associated with schizophrenia. Therefore, hippocampal volume may serve as a biomarker for psychosis. Several studies have already investigated hippocampal volume in CHR groups. Based on these studies, the present meta-analysis compares the baseline left and right hippocampal volume of CHR patients who developed a psychosis with that of CHR patients without such a transition. Our results show no statistically significant effect of the hippocampal volume on the transition risk for psychosis.

Original languageEnglish
Article number614659
JournalFrontiers in Psychiatry
Volume11
ISSN1664-0640
DOIs
Publication statusPublished - 14.01.2021

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