Does Breastmilk Influence the Development of Bronchopulmonary Dysplasia?

Juliane Spiegler; Michael Preuß; Corinna Gebauer; Meike Bendiks; Egbert Herting; Wolfgang Göpel; Martin A. Berghäuser; Kai Böckenholt; Bettina Bohnhorst; Ralf Böttger; Thomas Brune; Kristin Dawczynski; Michael Dördelmann; Silke Ehlers; Joachim G. Eichhorn; Ursula Felderhoff-Müser; Axel Franz; Hubert Gerleve; Ludwig Gortner; Roland Haase; Friedhelm Heitmann; Roland Hentschel; Nico Hepping; Georg Hillebrand; Thomas Höhn; Isabelle Hörnig-Franz; Mechthild Hubert; Andreas Jenke; Rainer Jensen; Olaf Kannt; Hans T. Körner; Angela Kribs; Helmut Küster; Knud Linnemann; Jens Möller; Andreas Müller; Dirk Müller; Dirk M. Olbertz; Thorsten Orlikowsky; Jochen Reese; Claudia Roll; Rainer Rossi; Mario Rüdiger; Thomas Schaible; Jan Holger Schiffmann; Susanne Schmidkte; Stephan Seeliger; Hugo Segerer; Jens Siegel; Norbert Teig; Florian Urlichs; Axel Von Der Wense; Matthias Vochem; Ursula Weller; Christian Wieg; Jürgen Wintgens

doi:10.1016/j.jpeds.2015.10.080

Does Breastmilk Influence the Development of Bronchopulmonary Dysplasia?

Juliane Spiegler^*, Michael Preuß, Corinna Gebauer, Meike Bendiks, Egbert Herting, Wolfgang Göpel, Martin A. Berghäuser, Kai Böckenholt, Bettina Bohnhorst, Ralf Böttger, Thomas Brune, Kristin Dawczynski, Michael Dördelmann, Silke Ehlers, Joachim G. Eichhorn, Ursula Felderhoff-Müser, Axel Franz, Hubert Gerleve, Ludwig Gortner, Roland HaaseFriedhelm Heitmann, Roland Hentschel, Nico Hepping, Georg Hillebrand, Thomas Höhn, Isabelle Hörnig-Franz, Mechthild Hubert, Andreas Jenke, Rainer Jensen, Olaf Kannt, Hans T. Körner, Angela Kribs, Helmut Küster, Knud Linnemann, Jens Möller, Andreas Müller, Dirk Müller, Dirk M. Olbertz, Thorsten Orlikowsky, Jochen Reese, Claudia Roll, Rainer Rossi, Mario Rüdiger, Thomas Schaible, Jan Holger Schiffmann, Susanne Schmidkte, Stephan Seeliger, Hugo Segerer, Jens Siegel, Norbert Teig, Florian Urlichs, Axel Von Der Wense, Matthias Vochem, Ursula Weller, Christian Wieg, Jürgen Wintgens

^*Corresponding author for this work

Clinic of Pediatric and Adolescent Medicine

University of Leipzig

72 Citations (Scopus)

Abstract

Objective To assess whether breastmilk feeding is associated with a reduced risk of bronchopulmonary dysplasia (BPD). Secondary outcome measures analyzed were retinopathy of prematurity (ROP) and necrotizing enterocolitis (NEC). Study design In an ongoing multicenter cohort study, the data of 1433 very low birth weight infants born before 32 weeks of gestation and discharged in 2013 were analyzed. We compared growth and neonatal complications of infants who received breastmilk exclusively (N = 223) with those who received formula feedings exclusively (N = 239). Logistic regression models were estimated for BPD, ROP, and NEC using nutrition as an independent variable. The Firth logistic regression model and Lasso were used for sensitivity analyses. Results Exclusively breastmilk-fed infants gained less weight compared with formula-fed infants. SDS for weight decreased between birth and discharge (median (Q1-Q3): formula -0.9 (-1.4 to [-0.5]) vs breastmilk -1.1 (-1.7 to [-0.6])). Exclusive formula feeding of very low birth weight infants was associated with increased risks of BPD (OR 2.6) as well as NEC (OR 12.6) and ROP (OR 1.80) after controlling for known risk factors. Conclusions Exclusive breastmilk feeding was associated with lower growth rates and a reduced risk of BPD as well as NEC and ROP.

Original language	English
Journal	Journal of Pediatrics
Volume	169
Pages (from-to)	76-80.e4
ISSN	0022-3476
DOIs	https://doi.org/10.1016/j.jpeds.2015.10.080
Publication status	Published - 01.02.2016

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10.1016/j.jpeds.2015.10.080

Cite this

Spiegler, J., Preuß, M., Gebauer, C., Bendiks, M., Herting, E., Göpel, W., Berghäuser, M. A., Böckenholt, K., Bohnhorst, B., Böttger, R., Brune, T., Dawczynski, K., Dördelmann, M., Ehlers, S., Eichhorn, J. G., Felderhoff-Müser, U., Franz, A., Gerleve, H., Gortner, L., ... Wintgens, J. (2016). Does Breastmilk Influence the Development of Bronchopulmonary Dysplasia? Journal of Pediatrics, 169, 76-80.e4. https://doi.org/10.1016/j.jpeds.2015.10.080

@article{437e7b7917344d94b53214e0f05dd593,

title = "Does Breastmilk Influence the Development of Bronchopulmonary Dysplasia?",

abstract = "Objective To assess whether breastmilk feeding is associated with a reduced risk of bronchopulmonary dysplasia (BPD). Secondary outcome measures analyzed were retinopathy of prematurity (ROP) and necrotizing enterocolitis (NEC). Study design In an ongoing multicenter cohort study, the data of 1433 very low birth weight infants born before 32 weeks of gestation and discharged in 2013 were analyzed. We compared growth and neonatal complications of infants who received breastmilk exclusively (N = 223) with those who received formula feedings exclusively (N = 239). Logistic regression models were estimated for BPD, ROP, and NEC using nutrition as an independent variable. The Firth logistic regression model and Lasso were used for sensitivity analyses. Results Exclusively breastmilk-fed infants gained less weight compared with formula-fed infants. SDS for weight decreased between birth and discharge (median (Q1-Q3): formula -0.9 (-1.4 to [-0.5]) vs breastmilk -1.1 (-1.7 to [-0.6])). Exclusive formula feeding of very low birth weight infants was associated with increased risks of BPD (OR 2.6) as well as NEC (OR 12.6) and ROP (OR 1.80) after controlling for known risk factors. Conclusions Exclusive breastmilk feeding was associated with lower growth rates and a reduced risk of BPD as well as NEC and ROP.",

author = "Juliane Spiegler and Michael Preu{\ss} and Corinna Gebauer and Meike Bendiks and Egbert Herting and Wolfgang G{\"o}pel and Bergh{\"a}user, {Martin A.} and Kai B{\"o}ckenholt and Bettina Bohnhorst and Ralf B{\"o}ttger and Thomas Brune and Kristin Dawczynski and Michael D{\"o}rdelmann and Silke Ehlers and Eichhorn, {Joachim G.} and Ursula Felderhoff-M{\"u}ser and Axel Franz and Hubert Gerleve and Ludwig Gortner and Roland Haase and Friedhelm Heitmann and Roland Hentschel and Nico Hepping and Georg Hillebrand and Thomas H{\"o}hn and Isabelle H{\"o}rnig-Franz and Mechthild Hubert and Andreas Jenke and Rainer Jensen and Olaf Kannt and K{\"o}rner, {Hans T.} and Angela Kribs and Helmut K{\"u}ster and Knud Linnemann and Jens M{\"o}ller and Andreas M{\"u}ller and Dirk M{\"u}ller and Olbertz, {Dirk M.} and Thorsten Orlikowsky and Jochen Reese and Claudia Roll and Rainer Rossi and Mario R{\"u}diger and Thomas Schaible and Schiffmann, {Jan Holger} and Susanne Schmidkte and Stephan Seeliger and Hugo Segerer and Jens Siegel and Norbert Teig and Florian Urlichs and Wense, {Axel Von Der} and Matthias Vochem and Ursula Weller and Christian Wieg and J{\"u}rgen Wintgens",

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day = "1",

doi = "10.1016/j.jpeds.2015.10.080",

language = "English",

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pages = "76--80.e4",

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Spiegler, J, Preuß, M, Gebauer, C, Bendiks, M, Herting, E, Göpel, W, Berghäuser, MA, Böckenholt, K, Bohnhorst, B, Böttger, R, Brune, T, Dawczynski, K, Dördelmann, M, Ehlers, S, Eichhorn, JG, Felderhoff-Müser, U, Franz, A, Gerleve, H, Gortner, L, Haase, R, Heitmann, F, Hentschel, R, Hepping, N, Hillebrand, G, Höhn, T, Hörnig-Franz, I, Hubert, M, Jenke, A, Jensen, R, Kannt, O, Körner, HT, Kribs, A, Küster, H, Linnemann, K, Möller, J, Müller, A, Müller, D, Olbertz, DM, Orlikowsky, T, Reese, J, Roll, C, Rossi, R, Rüdiger, M, Schaible, T, Schiffmann, JH, Schmidkte, S, Seeliger, S, Segerer, H, Siegel, J, Teig, N, Urlichs, F, Wense, AVD, Vochem, M, Weller, U, Wieg, C & Wintgens, J 2016, 'Does Breastmilk Influence the Development of Bronchopulmonary Dysplasia?', Journal of Pediatrics, vol. 169, pp. 76-80.e4. https://doi.org/10.1016/j.jpeds.2015.10.080