Does Breastmilk Influence the Development of Bronchopulmonary Dysplasia?

Juliane Spiegler*, Michael Preuß, Corinna Gebauer, Meike Bendiks, Egbert Herting, Wolfgang Göpel, Martin A. Berghäuser, Kai Böckenholt, Bettina Bohnhorst, Ralf Böttger, Thomas Brune, Kristin Dawczynski, Michael Dördelmann, Silke Ehlers, Joachim G. Eichhorn, Ursula Felderhoff-Müser, Axel Franz, Hubert Gerleve, Ludwig Gortner, Roland HaaseFriedhelm Heitmann, Roland Hentschel, Nico Hepping, Georg Hillebrand, Thomas Höhn, Isabelle Hörnig-Franz, Mechthild Hubert, Andreas Jenke, Rainer Jensen, Olaf Kannt, Hans T. Körner, Angela Kribs, Helmut Küster, Knud Linnemann, Jens Möller, Andreas Müller, Dirk Müller, Dirk M. Olbertz, Thorsten Orlikowsky, Jochen Reese, Claudia Roll, Rainer Rossi, Mario Rüdiger, Thomas Schaible, Jan Holger Schiffmann, Susanne Schmidkte, Stephan Seeliger, Hugo Segerer, Jens Siegel, Norbert Teig, Florian Urlichs, Axel Von Der Wense, Matthias Vochem, Ursula Weller, Christian Wieg, Jürgen Wintgens

*Corresponding author for this work
72 Citations (Scopus)


Objective To assess whether breastmilk feeding is associated with a reduced risk of bronchopulmonary dysplasia (BPD). Secondary outcome measures analyzed were retinopathy of prematurity (ROP) and necrotizing enterocolitis (NEC). Study design In an ongoing multicenter cohort study, the data of 1433 very low birth weight infants born before 32 weeks of gestation and discharged in 2013 were analyzed. We compared growth and neonatal complications of infants who received breastmilk exclusively (N = 223) with those who received formula feedings exclusively (N = 239). Logistic regression models were estimated for BPD, ROP, and NEC using nutrition as an independent variable. The Firth logistic regression model and Lasso were used for sensitivity analyses. Results Exclusively breastmilk-fed infants gained less weight compared with formula-fed infants. SDS for weight decreased between birth and discharge (median (Q1-Q3): formula -0.9 (-1.4 to [-0.5]) vs breastmilk -1.1 (-1.7 to [-0.6])). Exclusive formula feeding of very low birth weight infants was associated with increased risks of BPD (OR 2.6) as well as NEC (OR 12.6) and ROP (OR 1.80) after controlling for known risk factors. Conclusions Exclusive breastmilk feeding was associated with lower growth rates and a reduced risk of BPD as well as NEC and ROP.

Original languageEnglish
JournalJournal of Pediatrics
Pages (from-to)76-80.e4
Publication statusPublished - 01.02.2016


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