Disturbance of "Extrinsic Alertness" in huntington's disease

Sandra V. Müller*, Andrea Jung, Jens Preinfalk, Hans Kolbe, Maria Ridao-Alonso, Reinhard Dengler, Thomas F. Münte

*Corresponding author for this work
19 Citations (Scopus)

Abstract

Neuropsychological deficits are a main feature of Huntington's disease (HD) with previous data suggesting involvement of attentional functions. Attention can be divided into several different dimensions: intensity, selectivity and supervisory attentional control. These different aspects of attention were investigated in a group of 13 patients with HD and 13 healthy matched control subjects. HD patients were impaired mostly for the intensity dimension: contrary to controls, and like other neurological patient groups, they were not able to speed up their reaction times when an auditory warning stimulus preceded a visual target which suggests a deficit in 'extrinsic alertness.' In addition less severe impairments were found in the dimensions selectivity and supervisory attentional control.

Original languageEnglish
JournalJournal of Clinical and Experimental Neuropsychology
Volume24
Issue number4
Pages (from-to)517-526
Number of pages10
ISSN1380-3395
DOIs
Publication statusPublished - 25.07.2002

Research Areas and Centers

  • Academic Focus: Center for Brain, Behavior and Metabolism (CBBM)

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