TY - JOUR
T1 - Distribution and risk of the second discordant primary cancers combined after a specific first primary cancer in German and Swedish cancer registries
AU - GEKID Cancer Survival Workgroup
AU - Chen, Tianhui
AU - Fallah, Mahdi
AU - Jansen, Lina
AU - Castro, Felipe
AU - Krilavicuite, Agne
AU - Katalinic, Alexander
AU - Eisemann, Nora
AU - Emrich, Katharina
AU - Holleczek, Bernd
AU - Geiss, Karla
AU - Eberle, Andrea
AU - Sundquist, Jan
AU - Brenner, Hermann
AU - Hemminki, Kari
AU - Meyer, Martin
AU - Luttmann, Sabine
AU - Stabenow, Roland
AU - Hentschel, Stefan
AU - Nennecke, Alice
AU - Kieschke, Joachim
AU - Sirri, Eunice
AU - KajÜter, Hiltraud
AU - Mattauch, Volkmar
AU - Kraywinkel, Klaus
AU - Castro, Felipe
PY - 2015/12/1
Y1 - 2015/12/1
N2 - We aimed at investigating the distribution and risk of all second discordant primary cancers (SDPCs) after a specific first primary cancer in Germany and Sweden to provide etiological understanding of SDPCs and insight into their incidence rates and recording practices. Among 1,537,004 survivors of first primary cancers in Germany and 588,103 in Sweden, overall 80,162 and 32,544 SDPCs were recorded, respectively. Standardized incidence ratios (SIRs) of all SDPCs were elevated at levels between 1.1 and 2.1 after 23 (out of overall 29) cancers in Germany and at levels between 1.1 and 1.6 after 24 cancers in Sweden, and among them, elevated SIRs were found after 19 cancers in both populations. Decreased SIRs at levels ranging from 0.5 to 0.9 were found for some cancers with poor prognosis in Germany only. We found elevated risk after 19 out of 29 cancers in both countries, suggesting common etiology of SDPCs after most of first cancers and registration similarity. Decreased risks after some fatal cancers were found only in Germany, which may be attributed to reporting practices or missed death data in Germany.
AB - We aimed at investigating the distribution and risk of all second discordant primary cancers (SDPCs) after a specific first primary cancer in Germany and Sweden to provide etiological understanding of SDPCs and insight into their incidence rates and recording practices. Among 1,537,004 survivors of first primary cancers in Germany and 588,103 in Sweden, overall 80,162 and 32,544 SDPCs were recorded, respectively. Standardized incidence ratios (SIRs) of all SDPCs were elevated at levels between 1.1 and 2.1 after 23 (out of overall 29) cancers in Germany and at levels between 1.1 and 1.6 after 24 cancers in Sweden, and among them, elevated SIRs were found after 19 cancers in both populations. Decreased SIRs at levels ranging from 0.5 to 0.9 were found for some cancers with poor prognosis in Germany only. We found elevated risk after 19 out of 29 cancers in both countries, suggesting common etiology of SDPCs after most of first cancers and registration similarity. Decreased risks after some fatal cancers were found only in Germany, which may be attributed to reporting practices or missed death data in Germany.
UR - http://www.scopus.com/inward/record.url?scp=84943449154&partnerID=8YFLogxK
U2 - 10.1016/j.canlet.2015.08.014
DO - 10.1016/j.canlet.2015.08.014
M3 - Journal articles
C2 - 26319898
AN - SCOPUS:84943449154
SN - 0304-3835
VL - 369
SP - 152
EP - 166
JO - Cancer Letters
JF - Cancer Letters
IS - 1
ER -
