Distortion of Mendelian recovery ratio for a mouse HSR is caused by maternal and zygotic effects

Dieter Weichenhan; Walther Traut; Bärbel Kunze; Heinz Winking

doi:10.1017/s0016672300034017

Distortion of Mendelian recovery ratio for a mouse HSR is caused by maternal and zygotic effects

Dieter Weichenhan, Walther Traut, Bärbel Kunze, Heinz Winking^*

^*Corresponding author for this work

Institute of Biology

20 Citations (Scopus)

Abstract

An HSR in chromosome 1 which is found in many feral populations of Mus musculus domesticus was shown in previous studies to consist of a high-copy long-range repeat cluster. One such cluster, MUT, showed distorted transmission ratios when introduced by female parents. MUT/+ offspring were preferentially recovered at the expense of +/+ embryos in the progeny of ♀ MUT/+ x ♂ +/+ but were found at the expected 1:1 ratio in reciprocal crosses. Preferential recovery of maternal MUT was due to lethality of postimplantation +/+ embryos. There was no distortion of the recovery ratio in MUT/+ x MUT/MUT progeny: maternal MUT and + clusters were present among live implants at a 1:1 ratio. Maternal and zygotic effects therefore contribute to the phenomenon. The mechanism of their interaction is unknown.

Original language	English
Journal	Genetical Research
Volume	68
Issue number	2
Pages (from-to)	125-129
Number of pages	5
ISSN	0016-6723
DOIs	https://doi.org/10.1017/s0016672300034017
Publication status	Published - 10.1996

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Academic Focus: Center for Infection and Inflammation Research (ZIEL)

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title = "Distortion of Mendelian recovery ratio for a mouse HSR is caused by maternal and zygotic effects",

abstract = "An HSR in chromosome 1 which is found in many feral populations of Mus musculus domesticus was shown in previous studies to consist of a high-copy long-range repeat cluster. One such cluster, MUT, showed distorted transmission ratios when introduced by female parents. MUT/+ offspring were preferentially recovered at the expense of +/+ embryos in the progeny of ♀ MUT/+ x ♂ +/+ but were found at the expected 1:1 ratio in reciprocal crosses. Preferential recovery of maternal MUT was due to lethality of postimplantation +/+ embryos. There was no distortion of the recovery ratio in MUT/+ x MUT/MUT progeny: maternal MUT and + clusters were present among live implants at a 1:1 ratio. Maternal and zygotic effects therefore contribute to the phenomenon. The mechanism of their interaction is unknown.",

author = "Dieter Weichenhan and Walther Traut and B{\"a}rbel Kunze and Heinz Winking",

year = "1996",

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T1 - Distortion of Mendelian recovery ratio for a mouse HSR is caused by maternal and zygotic effects

AU - Weichenhan, Dieter

AU - Traut, Walther

AU - Kunze, Bärbel

AU - Winking, Heinz

PY - 1996/10

Y1 - 1996/10

N2 - An HSR in chromosome 1 which is found in many feral populations of Mus musculus domesticus was shown in previous studies to consist of a high-copy long-range repeat cluster. One such cluster, MUT, showed distorted transmission ratios when introduced by female parents. MUT/+ offspring were preferentially recovered at the expense of +/+ embryos in the progeny of ♀ MUT/+ x ♂ +/+ but were found at the expected 1:1 ratio in reciprocal crosses. Preferential recovery of maternal MUT was due to lethality of postimplantation +/+ embryos. There was no distortion of the recovery ratio in MUT/+ x MUT/MUT progeny: maternal MUT and + clusters were present among live implants at a 1:1 ratio. Maternal and zygotic effects therefore contribute to the phenomenon. The mechanism of their interaction is unknown.

AB - An HSR in chromosome 1 which is found in many feral populations of Mus musculus domesticus was shown in previous studies to consist of a high-copy long-range repeat cluster. One such cluster, MUT, showed distorted transmission ratios when introduced by female parents. MUT/+ offspring were preferentially recovered at the expense of +/+ embryos in the progeny of ♀ MUT/+ x ♂ +/+ but were found at the expected 1:1 ratio in reciprocal crosses. Preferential recovery of maternal MUT was due to lethality of postimplantation +/+ embryos. There was no distortion of the recovery ratio in MUT/+ x MUT/MUT progeny: maternal MUT and + clusters were present among live implants at a 1:1 ratio. Maternal and zygotic effects therefore contribute to the phenomenon. The mechanism of their interaction is unknown.

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Distortion of Mendelian recovery ratio for a mouse HSR is caused by maternal and zygotic effects

Abstract

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