Distal and proximal interleukin (IL)-10 promoter polymorphisms associated with risk of cutaneous melanoma development: A case-control study

N. Schoof; F. von Bonin; I. R. König; R. Mössner; U. Krüger; K. Reich; C. Berking; M. Volkenandt; A. Ziegler; L. Böckmann; C. Kuschal; K. M. Thoms; D. Kube; S. Emmert

doi:10.1038/gene.2009.40

Distal and proximal interleukin (IL)-10 promoter polymorphisms associated with risk of cutaneous melanoma development: A case-control study

N. Schoof, F. von Bonin, I. R. König, R. Mössner, U. Krüger, K. Reich, C. Berking, M. Volkenandt, A. Ziegler, L. Böckmann, C. Kuschal, K. M. Thoms, D. Kube^*, S. Emmert

^*Corresponding author for this work

Institute of Medical Biometry and Statistic

18 Citations (Scopus)

Abstract

Inherited promoter polymorphisms of the interleukin (IL)-10 gene resulting in altered IL-10 production may contribute to a genetic susceptibility for melanoma. We investigated the role of a haplotype from distal as well as proximal polymorphic sites [-7400InDel, -6752AT (rs6676671), -3538AT (rs1800890), -1087AG (rs1800896), -597AC (rs1800872)] of the IL-10 5′-flanking region in a hospital-based case-control study of 165 Caucasian patients with cutaneous melanoma from Germany in comparison with 162 healthy cancer-free Caucasian control participants from the same area matched by age. Using multivariate analysis for the number of nevi and skin type, the IL-10 'higher producing' haplotype ITAGC was found to be significantly associated with a reduced risk of developing melanoma (adjusted P=0.02). Although our findings need to be confirmed by independent and larger multicenter studies, we have described for the first time the association of distal gene variants of the IL-10 gene as an independent risk factor for melanoma.

Original language	English
Journal	Genes and Immunity
Volume	10
Issue number	6
Pages (from-to)	586-590
Number of pages	5
ISSN	1466-4879
DOIs	https://doi.org/10.1038/gene.2009.40
Publication status	Published - 2009

Funding

We are grateful to the Deutsche Forschungsgemeinschaft DFG (Graduate College 1034, www.gcpg.de) for supporting this work and the colleagues of the GRK1034 for helpful discussions.

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10.1038/gene.2009.40

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Schoof, N., von Bonin, F., König, I. R., Mössner, R., Krüger, U., Reich, K., Berking, C., Volkenandt, M., Ziegler, A., Böckmann, L., Kuschal, C., Thoms, K. M., Kube, D., & Emmert, S. (2009). Distal and proximal interleukin (IL)-10 promoter polymorphisms associated with risk of cutaneous melanoma development: A case-control study. Genes and Immunity, 10(6), 586-590. https://doi.org/10.1038/gene.2009.40

@article{d48b618cdb4e47c4817912defca17c02,

title = "Distal and proximal interleukin (IL)-10 promoter polymorphisms associated with risk of cutaneous melanoma development: A case-control study",

abstract = "Inherited promoter polymorphisms of the interleukin (IL)-10 gene resulting in altered IL-10 production may contribute to a genetic susceptibility for melanoma. We investigated the role of a haplotype from distal as well as proximal polymorphic sites [-7400InDel, -6752AT (rs6676671), -3538AT (rs1800890), -1087AG (rs1800896), -597AC (rs1800872)] of the IL-10 5′-flanking region in a hospital-based case-control study of 165 Caucasian patients with cutaneous melanoma from Germany in comparison with 162 healthy cancer-free Caucasian control participants from the same area matched by age. Using multivariate analysis for the number of nevi and skin type, the IL-10 'higher producing' haplotype ITAGC was found to be significantly associated with a reduced risk of developing melanoma (adjusted P=0.02). Although our findings need to be confirmed by independent and larger multicenter studies, we have described for the first time the association of distal gene variants of the IL-10 gene as an independent risk factor for melanoma.",

author = "N. Schoof and \{von Bonin\}, F. and K{\"o}nig, \{I. R.\} and R. M{\"o}ssner and U. Kr{\"u}ger and K. Reich and C. Berking and M. Volkenandt and A. Ziegler and L. B{\"o}ckmann and C. Kuschal and Thoms, \{K. M.\} and D. Kube and S. Emmert",

note = "Funding Information: We are grateful to the Deutsche Forschungsgemeinschaft DFG (Graduate College 1034, www.gcpg.de) for supporting this work and the colleagues of the GRK1034 for helpful discussions.",

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doi = "10.1038/gene.2009.40",

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Schoof, N, von Bonin, F, König, IR, Mössner, R, Krüger, U, Reich, K, Berking, C, Volkenandt, M, Ziegler, A, Böckmann, L, Kuschal, C, Thoms, KM, Kube, D & Emmert, S 2009, 'Distal and proximal interleukin (IL)-10 promoter polymorphisms associated with risk of cutaneous melanoma development: A case-control study', Genes and Immunity, vol. 10, no. 6, pp. 586-590. https://doi.org/10.1038/gene.2009.40

TY - JOUR

T1 - Distal and proximal interleukin (IL)-10 promoter polymorphisms associated with risk of cutaneous melanoma development: A case-control study

AU - Schoof, N.

AU - von Bonin, F.

AU - König, I. R.

AU - Mössner, R.

AU - Krüger, U.

AU - Reich, K.

AU - Berking, C.

AU - Volkenandt, M.

AU - Ziegler, A.

AU - Böckmann, L.

AU - Kuschal, C.

AU - Thoms, K. M.

AU - Kube, D.

AU - Emmert, S.

N1 - Funding Information: We are grateful to the Deutsche Forschungsgemeinschaft DFG (Graduate College 1034, www.gcpg.de) for supporting this work and the colleagues of the GRK1034 for helpful discussions.

PY - 2009

Y1 - 2009

N2 - Inherited promoter polymorphisms of the interleukin (IL)-10 gene resulting in altered IL-10 production may contribute to a genetic susceptibility for melanoma. We investigated the role of a haplotype from distal as well as proximal polymorphic sites [-7400InDel, -6752AT (rs6676671), -3538AT (rs1800890), -1087AG (rs1800896), -597AC (rs1800872)] of the IL-10 5′-flanking region in a hospital-based case-control study of 165 Caucasian patients with cutaneous melanoma from Germany in comparison with 162 healthy cancer-free Caucasian control participants from the same area matched by age. Using multivariate analysis for the number of nevi and skin type, the IL-10 'higher producing' haplotype ITAGC was found to be significantly associated with a reduced risk of developing melanoma (adjusted P=0.02). Although our findings need to be confirmed by independent and larger multicenter studies, we have described for the first time the association of distal gene variants of the IL-10 gene as an independent risk factor for melanoma.

AB - Inherited promoter polymorphisms of the interleukin (IL)-10 gene resulting in altered IL-10 production may contribute to a genetic susceptibility for melanoma. We investigated the role of a haplotype from distal as well as proximal polymorphic sites [-7400InDel, -6752AT (rs6676671), -3538AT (rs1800890), -1087AG (rs1800896), -597AC (rs1800872)] of the IL-10 5′-flanking region in a hospital-based case-control study of 165 Caucasian patients with cutaneous melanoma from Germany in comparison with 162 healthy cancer-free Caucasian control participants from the same area matched by age. Using multivariate analysis for the number of nevi and skin type, the IL-10 'higher producing' haplotype ITAGC was found to be significantly associated with a reduced risk of developing melanoma (adjusted P=0.02). Although our findings need to be confirmed by independent and larger multicenter studies, we have described for the first time the association of distal gene variants of the IL-10 gene as an independent risk factor for melanoma.

UR - https://www.scopus.com/pages/publications/69949165787

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DO - 10.1038/gene.2009.40

M3 - Journal articles

C2 - 19458621

AN - SCOPUS:69949165787

SN - 1466-4879

VL - 10

SP - 586

EP - 590

JO - Genes and Immunity

JF - Genes and Immunity

IS - 6

ER -

Distal and proximal interleukin (IL)-10 promoter polymorphisms associated with risk of cutaneous melanoma development: A case-control study

Abstract

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