Distal and proximal interleukin (IL)-10 promoter polymorphisms associated with risk of cutaneous melanoma development: A case-control study

N. Schoof, F. von Bonin, I. R. König, R. Mössner, U. Krüger, K. Reich, C. Berking, M. Volkenandt, A. Ziegler, L. Böckmann, C. Kuschal, K. M. Thoms, D. Kube*, S. Emmert

*Corresponding author for this work
17 Citations (Scopus)

Abstract

Inherited promoter polymorphisms of the interleukin (IL)-10 gene resulting in altered IL-10 production may contribute to a genetic susceptibility for melanoma. We investigated the role of a haplotype from distal as well as proximal polymorphic sites [-7400InDel, -6752AT (rs6676671), -3538AT (rs1800890), -1087AG (rs1800896), -597AC (rs1800872)] of the IL-10 5′-flanking region in a hospital-based case-control study of 165 Caucasian patients with cutaneous melanoma from Germany in comparison with 162 healthy cancer-free Caucasian control participants from the same area matched by age. Using multivariate analysis for the number of nevi and skin type, the IL-10 'higher producing' haplotype ITAGC was found to be significantly associated with a reduced risk of developing melanoma (adjusted P=0.02). Although our findings need to be confirmed by independent and larger multicenter studies, we have described for the first time the association of distal gene variants of the IL-10 gene as an independent risk factor for melanoma.

Original languageEnglish
JournalGenes and Immunity
Volume10
Issue number6
Pages (from-to)586-590
Number of pages5
ISSN1466-4879
DOIs
Publication statusPublished - 2009

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