Digital Zebrafish Phantom based on Micro-CT Data for Imaging Research

M. Zvolsky; N. Schreiner; S. Seeger; M. Schaar; S. Rakers; Magdalena Rafecas

doi:10.1109/NSS/MIC42101.2019.9059702

Abstract

Numerical simulations, including Monte Carlo techniques, are a powerful tool for characterising, evaluating and optimising medical imaging devices and techniques. A vital aspect of simulations is to have a realistic phantom or model of the subject's anatomy. The present work describes the measurement and image processing strategies that lead to a computer phantom of a zebrafish (Danio rerio), based on ex-vivo micro-CT scans. Different fixation methods were investigated. The fixation in formalin lead to the best soft-tissue contrast while preventing the fish from drying. A preliminary digital zebrafish model is presented here.

Original language	English
DOIs	https://doi.org/10.1109/NSS/MIC42101.2019.9059702
Publication status	Published - 10.2019
Event	2019 IEEE Nuclear Science Symposium and Medical Imaging Conference - Manchester, United Kingdom Duration: 26.10.2019 → 02.11.2019 Conference number: 159071

Conference

Conference	2019 IEEE Nuclear Science Symposium and Medical Imaging Conference
Abbreviated title	NSS/MIC 2019
Country/Territory	United Kingdom
City	Manchester
Period	26.10.19 → 02.11.19

UN SDGs

This output contributes to the following UN Sustainable Development Goals (SDGs)

SDG 3 Good Health and Well-being
SDG 9 Industry, Innovation, and Infrastructure

Research Areas and Centers

Academic Focus: Biomedical Engineering

DFG Research Classification Scheme

2.22-32 Medical Physics, Biomedical Technology

Access to Document

10.1109/NSS/MIC42101.2019.9059702

Cite this

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abstract = "Numerical simulations, including Monte Carlo techniques, are a powerful tool for characterising, evaluating and optimising medical imaging devices and techniques. A vital aspect of simulations is to have a realistic phantom or model of the subject's anatomy. The present work describes the measurement and image processing strategies that lead to a computer phantom of a zebrafish (Danio rerio), based on ex-vivo micro-CT scans. Different fixation methods were investigated. The fixation in formalin lead to the best soft-tissue contrast while preventing the fish from drying. A preliminary digital zebrafish model is presented here.",

author = "M. Zvolsky and N. Schreiner and S. Seeger and M. Schaar and S. Rakers and Magdalena Rafecas",

note = "Funding Information: This research project is part of ATTRACT that has received funding from the European Union{\textquoteright}s Horizon 2020 Research and Innovation Programme. Publisher Copyright: {\textcopyright} 2019 IEEE. Copyright: Copyright 2020 Elsevier B.V., All rights reserved.; 2019 IEEE Nuclear Science Symposium and Medical Imaging Conference, NSS/MIC 2019 ; Conference date: 26-10-2019 Through 02-11-2019",

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AU - Zvolsky, M.

AU - Schreiner, N.

AU - Seeger, S.

AU - Schaar, M.

AU - Rakers, S.

AU - Rafecas, Magdalena

N1 - Conference code: 159071

PY - 2019/10

Y1 - 2019/10

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AB - Numerical simulations, including Monte Carlo techniques, are a powerful tool for characterising, evaluating and optimising medical imaging devices and techniques. A vital aspect of simulations is to have a realistic phantom or model of the subject's anatomy. The present work describes the measurement and image processing strategies that lead to a computer phantom of a zebrafish (Danio rerio), based on ex-vivo micro-CT scans. Different fixation methods were investigated. The fixation in formalin lead to the best soft-tissue contrast while preventing the fish from drying. A preliminary digital zebrafish model is presented here.

UR - https://www.scopus.com/pages/publications/85083558352

U2 - 10.1109/NSS/MIC42101.2019.9059702

DO - 10.1109/NSS/MIC42101.2019.9059702

M3 - Abstracts

T2 - 2019 IEEE Nuclear Science Symposium and Medical Imaging Conference

Y2 - 26 October 2019 through 2 November 2019

ER -