Digital Zebrafish Phantom based on Micro-CT Data for Imaging Research

M. Zvolsky; N. Schreiner; S. Seeger; M. Schaar; S. Rakers; M. Rafecas

doi:10.1109/NSS/MIC42101.2019.9059702

Digital Zebrafish Phantom based on Micro-CT Data for Imaging Research

M. Zvolsky, N. Schreiner, S. Seeger, M. Schaar, S. Rakers, M. Rafecas

Institute of Medical Engineering

Abstract

Numerical simulations, including Monte Carlo techniques, are a powerful tool for characterising, evaluating and optimising medical imaging devices and techniques. A vital aspect of simulations is to have a realistic phantom or model of the subject's anatomy. The present work describes the measurement and image processing strategies that lead to a computer phantom of a zebrafish (Danio rerio), based on ex-vivo micro-CT scans. Different fixation methods were investigated. The fixation in formalin lead to the best soft-tissue contrast while preventing the fish from drying. A preliminary digital zebrafish model is presented here.

Original language	English
Title of host publication	2019 IEEE Nuclear Science Symposium and Medical Imaging Conference (NSS/MIC)
Publisher	IEEE
Publication date	10.2019
ISBN (Print)	978-1-7281-4165-7
ISBN (Electronic)	978-1-7281-4164-0
DOIs	https://doi.org/10.1109/NSS/MIC42101.2019.9059702
Publication status	Published - 10.2019
Event	2019 IEEE Nuclear Science Symposium and Medical Imaging Conference - Manchester, United Kingdom Duration: 26.10.2019 → 02.11.2019 Conference number: 159071

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10.1109/NSS/MIC42101.2019.9059702

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abstract = "Numerical simulations, including Monte Carlo techniques, are a powerful tool for characterising, evaluating and optimising medical imaging devices and techniques. A vital aspect of simulations is to have a realistic phantom or model of the subject's anatomy. The present work describes the measurement and image processing strategies that lead to a computer phantom of a zebrafish (Danio rerio), based on ex-vivo micro-CT scans. Different fixation methods were investigated. The fixation in formalin lead to the best soft-tissue contrast while preventing the fish from drying. A preliminary digital zebrafish model is presented here.",

author = "M. Zvolsky and N. Schreiner and S. Seeger and M. Schaar and S. Rakers and M. Rafecas",

note = "Funding Information: This research project is part of ATTRACT that has received funding from the European Union{\textquoteright}s Horizon 2020 Research and Innovation Programme. Publisher Copyright: {\textcopyright} 2019 IEEE. Copyright: Copyright 2020 Elsevier B.V., All rights reserved.; 2019 IEEE Nuclear Science Symposium and Medical Imaging Conference, NSS/MIC 2019 ; Conference date: 26-10-2019 Through 02-11-2019",

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Zvolsky, M, Schreiner, N, Seeger, S , Schaar, M, Rakers, S & Rafecas, M 2019, Digital Zebrafish Phantom based on Micro-CT Data for Imaging Research. in 2019 IEEE Nuclear Science Symposium and Medical Imaging Conference (NSS/MIC). IEEE Nuclear Science Symposium and Medical Imaging Conference, IEEE, 2019 IEEE Nuclear Science Symposium and Medical Imaging Conference, Manchester, United Kingdom, 26.10.19. https://doi.org/10.1109/NSS/MIC42101.2019.9059702

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AU - Rafecas, M.

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AB - Numerical simulations, including Monte Carlo techniques, are a powerful tool for characterising, evaluating and optimising medical imaging devices and techniques. A vital aspect of simulations is to have a realistic phantom or model of the subject's anatomy. The present work describes the measurement and image processing strategies that lead to a computer phantom of a zebrafish (Danio rerio), based on ex-vivo micro-CT scans. Different fixation methods were investigated. The fixation in formalin lead to the best soft-tissue contrast while preventing the fish from drying. A preliminary digital zebrafish model is presented here.

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ER -

Digital Zebrafish Phantom based on Micro-CT Data for Imaging Research

Abstract

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