TY - JOUR
T1 - Differential influence of 1,8-Cineol on distinct hypoxia-related immune alterations in human monocytes
AU - Jagodzinski, Nele
AU - Leichtle, Anke
AU - Depping, Reinhard
AU - Plötze-Martin, Kirstin
AU - Hakim, Samer G.
AU - Bruchhage, Karl Ludwig
AU - Pries, Ralph
N1 - Publisher Copyright:
© The Author(s) 2025.
PY - 2025/4/9
Y1 - 2025/4/9
N2 - 1,8-Cineol is a natural plant-based therapeutic agent and is commonly used to treat a broad range of acute and chronic airway inflammatory diseases. 1,8-Cineol has recently been shown to attenuate the checkpoint molecule PDL-1 in circulating monocytes in patients with chronic Otitis media (OM) and was associated with an improved clinical outcome. Hypoxia-inducible factor (HIF) is thought to play an essential role in the middle ear inflammatory process, mainly due to dysfunctions of the eustachian tube. However, the unambiguous impact of 1,8-Cineol on hypoxia-driven immune alterations of human monocytes and the related inflammatory microenvironment have not been investigated thus far. Therefore, we used the human monocytes to investigate the impact of 1,8-Cineol on the cellular hypoxia response with regards to expression levels of different adhesion molecules, chemokine receptors, and different cell stress-related proteins. Furthermore, the secretion patterns of a variety of chemokines and cytokines were evaluated. The study aimed to better understand the influence of the monoterpene 1,8-Cineol on hypoxia and normoxia-associated monocyte characteristics and related inflammatory processes, all of which are crucial for the development of various human diseases.
AB - 1,8-Cineol is a natural plant-based therapeutic agent and is commonly used to treat a broad range of acute and chronic airway inflammatory diseases. 1,8-Cineol has recently been shown to attenuate the checkpoint molecule PDL-1 in circulating monocytes in patients with chronic Otitis media (OM) and was associated with an improved clinical outcome. Hypoxia-inducible factor (HIF) is thought to play an essential role in the middle ear inflammatory process, mainly due to dysfunctions of the eustachian tube. However, the unambiguous impact of 1,8-Cineol on hypoxia-driven immune alterations of human monocytes and the related inflammatory microenvironment have not been investigated thus far. Therefore, we used the human monocytes to investigate the impact of 1,8-Cineol on the cellular hypoxia response with regards to expression levels of different adhesion molecules, chemokine receptors, and different cell stress-related proteins. Furthermore, the secretion patterns of a variety of chemokines and cytokines were evaluated. The study aimed to better understand the influence of the monoterpene 1,8-Cineol on hypoxia and normoxia-associated monocyte characteristics and related inflammatory processes, all of which are crucial for the development of various human diseases.
UR - http://www.scopus.com/inward/record.url?scp=105003194289&partnerID=8YFLogxK
UR - https://www.mendeley.com/catalogue/c306d5ee-4b56-3b6f-a533-2947b5902bcb/
U2 - 10.1038/s41598-025-97314-7
DO - 10.1038/s41598-025-97314-7
M3 - Journal articles
C2 - 40204839
AN - SCOPUS:105003194289
SN - 2045-2322
VL - 15
SP - 12126
JO - Scientific Reports
JF - Scientific Reports
IS - 1
M1 - 12126
ER -
