Abstract
The abundance of macrophages in localized cutaneous leishmaniasis (LCL) and diffuse cutaneous leishmaniasis (DCL) lesions and differences in the composition oft cell subsets indicate involvement of cell-specific chemotaxis processes. The expression of macrophage chemoattractant protein (MCP)-1, macrophage inflammatory protein (MIP)-1α and -1β, RANTES (regulated on activation, normal T cell expressed and secreted), 1-309, and interleukin-8 were investigated in lesions of patients with LCL or DCL. In LCL, high levels of MCP-1 and moderate levels of MIP-1α were detected. In DCL, MCP-1 expression was significantly lower and MIP-1α expression was predominant. All other chemokines investigated were minimally expressed or absent. These findings suggest that MCP-1 and MIP-1α are responsible for the recruitment of macrophages and T cells in cutaneous leishmaniasis. The results show that self-healing LCL is associated with higher levels of MCP-1, which may stimulate macrophage microbicidal mechanisms, and nonhealing DCL is associated with higher levels of MIP-1α.
| Original language | English |
|---|---|
| Journal | Journal of Infectious Diseases |
| Volume | 173 |
| Issue number | 3 |
| Pages (from-to) | 699-709 |
| Number of pages | 11 |
| ISSN | 0022-1899 |
| DOIs | |
| Publication status | Published - 01.01.1996 |
Funding
Received 2 August 1995; revised 31 October 1995. Presented in part: IVth International Symposium on Chernokines, Bath, United Kingdom, 27-30 June 1995. Informed consent was obtained from the patients. Human experimentation guidelines of the US Department of Health and Human Services and those of the authors' institution were followed in the conduct of the clinical research. The study was reviewed and approved by institutional ethics committees. Financial support: Bundesministerium fur Forschung und Technologie, Germany (KI 8906/0); Commission of the European Community (CT930314); Consejo Nacional de Ciencia y Tecnologia (Mexico; Il90-N9203); Direccion general de asuntos del personal academico (Mexico; IN-203892). Reprints or correspondence: Dr. Reinhard Gillitzer, Dept. of Dermatology, Universitat Wurzburg, Josef-Schneider-Str. 2, 97080 Wiirzburg, Germany.
Research Areas and Centers
- Academic Focus: Center for Infection and Inflammation Research (ZIEL)
