Differential expression of chemokines in patients with localized and diffuse cutaneous American leishmaniasis

Uwe Ritter, Heidrun Moll, Tamás Laskay, Eva Bettina Bröcker, Oscar Velazco, Ingeborg Becker, Reinhard Gillitzer*

*Corresponding author for this work
97 Citations (Scopus)


The abundance of macrophages in localized cutaneous leishmaniasis (LCL) and diffuse cutaneous leishmaniasis (DCL) lesions and differences in the composition oft cell subsets indicate involvement of cell-specific chemotaxis processes. The expression of macrophage chemoattractant protein (MCP)-1, macrophage inflammatory protein (MIP)-1α and -1β, RANTES (regulated on activation, normal T cell expressed and secreted), 1-309, and interleukin-8 were investigated in lesions of patients with LCL or DCL. In LCL, high levels of MCP-1 and moderate levels of MIP-1α were detected. In DCL, MCP-1 expression was significantly lower and MIP-1α expression was predominant. All other chemokines investigated were minimally expressed or absent. These findings suggest that MCP-1 and MIP-1α are responsible for the recruitment of macrophages and T cells in cutaneous leishmaniasis. The results show that self-healing LCL is associated with higher levels of MCP-1, which may stimulate macrophage microbicidal mechanisms, and nonhealing DCL is associated with higher levels of MIP-1α.

Original languageEnglish
JournalJournal of Infectious Diseases
Issue number3
Pages (from-to)699-709
Number of pages11
Publication statusPublished - 01.01.1996

Research Areas and Centers

  • Academic Focus: Center for Infection and Inflammation Research (ZIEL)


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