Differential brain activation according to chronic social reward frustration

Johannes Siegrist*, Ingo Menrath, Tony Stöcker, Martina Klein, Thilo Kellermann, N. Jon Shah, Karl Zilles, Frank Schneider

*Corresponding author for this work
41 Citations (Scopus)


Neural correlates of reward frustration are increasingly studied in humans. In line with prediction error theory, omission of an expected reward is associated with relative decreases of cerebral activation in dopaminergic brain areas. We investigated whether a history of chronic work-related reward frustration influences this reward-dependent activation pattern by means of functional magnetic resonance imaging. Solving arithmetic tasks was followed by either monetary reward or omission of reward. Hyperactivations in the medial prefrontal, anterior cingulate and dorsolateral prefrontal cortex were observed in a group of healthy adults with high susceptibility to reward frustration as compared with a group with low susceptibility. Findings indicate a compromised ability of adapting brain activation among those suffering form chronic social reward frustration.

Original languageEnglish
Issue number17
Pages (from-to)1899-1903
Number of pages5
Publication statusPublished - 28.11.2005

Research Areas and Centers

  • Academic Focus: Center for Brain, Behavior and Metabolism (CBBM)


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