Different regional brain volume loss in pure and complicated hereditary spastic paraparesis: A voxel-based morphometric study

Jan Kassubek*, Freimut D. Juengling, Annette Baumgartner, Alexander Unrath, Albert C. Ludolph, Anne D. Sperfeld

*Corresponding author for this work
14 Citations (Scopus)


Three-dimensional magnetic resonance imaging of the brain was analyzed using optimized voxel-based morphometry in 21 patients with pure hereditary spastic paraparesis (pHSP) and 12 patients with complicated HSP (cHSP). PHSP patients showed only small regional grey matter volume reduction, whereas significantly decreased grey matter volumes were localized pericentrally in cHSP. In the white matter, several small areas of regional volume reduction were observed in the pHSP patients, whereas the cHSP group exhibited large robust volume reduction involving the entire corpus callosum, a result that was reproduced by an additional region-based MRI analysis. It could be demonstrated that the topography of cerebral volume changes differed markedly in pHSP or cHSP at group level. Corpus callosum thinning seems to be a general feature of cHSP.

Original languageEnglish
JournalAmyotrophic Lateral Sclerosis
Issue number6
Pages (from-to)328-336
Number of pages9
Publication statusPublished - 2007

Research Areas and Centers

  • Health Sciences

DFG Research Classification Scheme

  • 206-08 Cognitive and Systemic Human Neuroscience
  • 206-05 Experimental Models for Investigating Diseases of the Nervous System
  • 206-07 Clinical Neurology Neurosurgery and Neuroradiology

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