Different regional brain volume loss in pure and complicated hereditary spastic paraparesis: A voxel-based morphometric study

Jan Kassubek; Freimut D. Juengling; Annette Baumgartner; Alexander Unrath; Albert C. Ludolph; Anne D. Sperfeld

doi:10.1080/17482960701500718

Different regional brain volume loss in pure and complicated hereditary spastic paraparesis: A voxel-based morphometric study

Jan Kassubek^*, Freimut D. Juengling, Annette Baumgartner, Alexander Unrath, Albert C. Ludolph, Anne D. Sperfeld

^*Corresponding author for this work

Institute of Health Sciences

14 Citations (Scopus)

Abstract

Three-dimensional magnetic resonance imaging of the brain was analyzed using optimized voxel-based morphometry in 21 patients with pure hereditary spastic paraparesis (pHSP) and 12 patients with complicated HSP (cHSP). PHSP patients showed only small regional grey matter volume reduction, whereas significantly decreased grey matter volumes were localized pericentrally in cHSP. In the white matter, several small areas of regional volume reduction were observed in the pHSP patients, whereas the cHSP group exhibited large robust volume reduction involving the entire corpus callosum, a result that was reproduced by an additional region-based MRI analysis. It could be demonstrated that the topography of cerebral volume changes differed markedly in pHSP or cHSP at group level. Corpus callosum thinning seems to be a general feature of cHSP.

Original language	English
Journal	Amyotrophic Lateral Sclerosis
Volume	8
Issue number	6
Pages (from-to)	328-336
Number of pages	9
ISSN	1748-2968
DOIs	https://doi.org/10.1080/17482960701500718
Publication status	Published - 2007

Research Areas and Centers

Health Sciences

DFG Research Classification Scheme

206-08 Cognitive and Systemic Human Neuroscience
206-05 Experimental Models for Investigating Diseases of the Nervous System
206-07 Clinical Neurology Neurosurgery and Neuroradiology

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This output contributes to the following UN Sustainable Development Goals (SDGs)

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10.1080/17482960701500718

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title = "Different regional brain volume loss in pure and complicated hereditary spastic paraparesis: A voxel-based morphometric study",

abstract = "Three-dimensional magnetic resonance imaging of the brain was analyzed using optimized voxel-based morphometry in 21 patients with pure hereditary spastic paraparesis (pHSP) and 12 patients with complicated HSP (cHSP). PHSP patients showed only small regional grey matter volume reduction, whereas significantly decreased grey matter volumes were localized pericentrally in cHSP. In the white matter, several small areas of regional volume reduction were observed in the pHSP patients, whereas the cHSP group exhibited large robust volume reduction involving the entire corpus callosum, a result that was reproduced by an additional region-based MRI analysis. It could be demonstrated that the topography of cerebral volume changes differed markedly in pHSP or cHSP at group level. Corpus callosum thinning seems to be a general feature of cHSP.",

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T1 - Different regional brain volume loss in pure and complicated hereditary spastic paraparesis

T2 - A voxel-based morphometric study

AU - Kassubek, Jan

AU - Juengling, Freimut D.

AU - Baumgartner, Annette

AU - Unrath, Alexander

AU - Ludolph, Albert C.

AU - Sperfeld, Anne D.

PY - 2007

Y1 - 2007

N2 - Three-dimensional magnetic resonance imaging of the brain was analyzed using optimized voxel-based morphometry in 21 patients with pure hereditary spastic paraparesis (pHSP) and 12 patients with complicated HSP (cHSP). PHSP patients showed only small regional grey matter volume reduction, whereas significantly decreased grey matter volumes were localized pericentrally in cHSP. In the white matter, several small areas of regional volume reduction were observed in the pHSP patients, whereas the cHSP group exhibited large robust volume reduction involving the entire corpus callosum, a result that was reproduced by an additional region-based MRI analysis. It could be demonstrated that the topography of cerebral volume changes differed markedly in pHSP or cHSP at group level. Corpus callosum thinning seems to be a general feature of cHSP.

AB - Three-dimensional magnetic resonance imaging of the brain was analyzed using optimized voxel-based morphometry in 21 patients with pure hereditary spastic paraparesis (pHSP) and 12 patients with complicated HSP (cHSP). PHSP patients showed only small regional grey matter volume reduction, whereas significantly decreased grey matter volumes were localized pericentrally in cHSP. In the white matter, several small areas of regional volume reduction were observed in the pHSP patients, whereas the cHSP group exhibited large robust volume reduction involving the entire corpus callosum, a result that was reproduced by an additional region-based MRI analysis. It could be demonstrated that the topography of cerebral volume changes differed markedly in pHSP or cHSP at group level. Corpus callosum thinning seems to be a general feature of cHSP.

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DO - 10.1080/17482960701500718

M3 - Journal articles

C2 - 17852008

AN - SCOPUS:36549067287

SN - 1748-2968

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Different regional brain volume loss in pure and complicated hereditary spastic paraparesis: A voxel-based morphometric study

Abstract

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