Different modes of hypervariability in (GATA)n simple sequence repeat loci

J. Rohwedel; D. Weichenhan; C. Meier; W. Traut

doi:10.1111/j.1365-2583.1993.tb00125.x

Different modes of hypervariability in (GATA)_n simple sequence repeat loci

J. Rohwedel^*, D. Weichenhan, C. Meier, W. Traut

^*Corresponding author for this work

Institute of Virology and Cell Biology

4 Citations (Scopus)

Abstract

Only a few prominent simple sequence repeat (SSR) loci of the type (GATA)_n are found in the genome of the mealmoth Ephestia kuehniella Zeller. Therefore this moth was chosen as a model organism for the genetic and molecular analysis of hypervariability of SSR loci. We characterized alleles of (GATA)_n loci in different Ephestia strains by cloning and genomic restriction mapping. Some variants appeared to be mere variable number of tandem repeat (VNTR) alleles, others showed considerable changes in the sequence neighbourhood of the GATA repeats. These may be produced by major rearrangements or by transposition of the (GATA)_n block together with flanking sequences into a different sequence environment.

Original language	English
Journal	Insect Molecular Biology
Volume	2
Issue number	1
Pages (from-to)	49-58
Number of pages	10
ISSN	0962-1075
DOIs	https://doi.org/10.1111/j.1365-2583.1993.tb00125.x
Publication status	Published - 01.01.1993

Research Areas and Centers

Academic Focus: Center for Infection and Inflammation Research (ZIEL)

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This output contributes to the following UN Sustainable Development Goals (SDGs)

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10.1111/j.1365-2583.1993.tb00125.x

Cite this

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abstract = "Only a few prominent simple sequence repeat (SSR) loci of the type (GATA)n are found in the genome of the mealmoth Ephestia kuehniella Zeller. Therefore this moth was chosen as a model organism for the genetic and molecular analysis of hypervariability of SSR loci. We characterized alleles of (GATA)n loci in different Ephestia strains by cloning and genomic restriction mapping. Some variants appeared to be mere variable number of tandem repeat (VNTR) alleles, others showed considerable changes in the sequence neighbourhood of the GATA repeats. These may be produced by major rearrangements or by transposition of the (GATA)n block together with flanking sequences into a different sequence environment.",

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AU - Weichenhan, D.

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