Differences in CCR5 expression on peripheral blood CD4+CD28- T-cells and in granulomatous lesions between localized and generalized Wegener's granulomatosis

Peter Lamprecht; Hilke Bruhl; Anika Erdmann; Konstanze Holl-Ulrich; Elena Csernok; Ulrike Seitzer; Matthias Mack; Alfred C. Feller; Eva Reinhold-Keller; Wolfgang L. Gross; Antje Muller

doi:10.1016/S1521-6616(03)00121-9

Differences in CCR5 expression on peripheral blood CD4⁺CD28^- T-cells and in granulomatous lesions between localized and generalized Wegener's granulomatosis

Peter Lamprecht^*, Hilke Bruhl, Anika Erdmann, Konstanze Holl-Ulrich, Elena Csernok, Ulrike Seitzer, Matthias Mack, Alfred C. Feller, Eva Reinhold-Keller, Wolfgang L. Gross, Antje Muller

^*Corresponding author for this work

58 Citations (Scopus)

Abstract

Wegener's granulomatosis (WG) is an autoimmune disease characterized by granulomatous lesions and a necrotizing vasculitis. Th1-type-cells lacking CD28 are expanded independent of age and immunosuppressive therapy in WG. To address their migratory properties of CD4⁺CD28^- T-cells we studied the expression of the inducible inflammatory Th1-type chemokine receptor CCR5 in localized WG and generalized WG. Expansion of CD4⁺CD28^- T-cells was more prominent in generalized WG compared to localized WG. In localized WG a larger fraction of CD4⁺CD28^- T-cells displayed CCR5 expression compared to generalized WG. CCR5 expression was also higher in granulomatous lesions in localized WG. Higher levels of CCR5 expression on CD4⁺CD28^- T-cells in localized WG may favor stronger CCR5-mediated recruitment of this T-cell subset into granulomatous lesions in localized WG. Expansion of Th-1-type CD4⁺CD28^-CCR5⁺ effector memory T-cells might contribute to disease progression and autoreactivity, either directly, by maintaining the inflammatory response, or as a result of bystander activation.

Original language	English
Journal	Clinical Immunology
Volume	108
Issue number	1
Pages (from-to)	1-7
Number of pages	7
ISSN	1521-6616
DOIs	https://doi.org/10.1016/S1521-6616(03)00121-9
Publication status	Published - 01.07.2003

Funding

Supported by Grants SFB367/C1 (U.S.) and SFB 367/A8 (P.L., A.M., and W.L.G.) from the German Research Society (Deutsche Forschungsgemeinschaft/DFG), and Grants No. 0.2 and 02.2 from the Verein zur Foerderung der Erforschung und Bekaempfung rheumatischer Erkrankungen Bad Bramstedt e.V. (A.M. and P.L.). We thank Kirsten Barre, Linda Carstens, Isabell Wenzel, and Gabriele Feldhoff for excellent technical assistance. We are grateful to the patients for their cooperation.

Research Areas and Centers

Academic Focus: Center for Infection and Inflammation Research (ZIEL)

UN SDGs

This output contributes to the following UN Sustainable Development Goals (SDGs)

Access to Document

10.1016/S1521-6616(03)00121-9

Cite this

Lamprecht, P., Bruhl, H., Erdmann, A., Holl-Ulrich, K., Csernok, E., Seitzer, U., Mack, M., Feller, A. C., Reinhold-Keller, E., Gross, W. L., & Muller, A. (2003). Differences in CCR5 expression on peripheral blood CD4⁺CD28^- T-cells and in granulomatous lesions between localized and generalized Wegener's granulomatosis. Clinical Immunology, 108(1), 1-7. https://doi.org/10.1016/S1521-6616(03)00121-9

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title = "Differences in CCR5 expression on peripheral blood CD4+CD28- T-cells and in granulomatous lesions between localized and generalized Wegener's granulomatosis",

abstract = "Wegener's granulomatosis (WG) is an autoimmune disease characterized by granulomatous lesions and a necrotizing vasculitis. Th1-type-cells lacking CD28 are expanded independent of age and immunosuppressive therapy in WG. To address their migratory properties of CD4+CD28- T-cells we studied the expression of the inducible inflammatory Th1-type chemokine receptor CCR5 in localized WG and generalized WG. Expansion of CD4+CD28- T-cells was more prominent in generalized WG compared to localized WG. In localized WG a larger fraction of CD4+CD28- T-cells displayed CCR5 expression compared to generalized WG. CCR5 expression was also higher in granulomatous lesions in localized WG. Higher levels of CCR5 expression on CD4+CD28- T-cells in localized WG may favor stronger CCR5-mediated recruitment of this T-cell subset into granulomatous lesions in localized WG. Expansion of Th-1-type CD4+CD28-CCR5+ effector memory T-cells might contribute to disease progression and autoreactivity, either directly, by maintaining the inflammatory response, or as a result of bystander activation.",

author = "Peter Lamprecht and Hilke Bruhl and Anika Erdmann and Konstanze Holl-Ulrich and Elena Csernok and Ulrike Seitzer and Matthias Mack and Feller, \{Alfred C.\} and Eva Reinhold-Keller and Gross, \{Wolfgang L.\} and Antje Muller",

note = "Funding Information: Supported by Grants SFB367/C1 (U.S.) and SFB 367/A8 (P.L., A.M., and W.L.G.) from the German Research Society (Deutsche Forschungsgemeinschaft/DFG), and Grants No. 0.2 and 02.2 from the Verein zur Foerderung der Erforschung und Bekaempfung rheumatischer Erkrankungen Bad Bramstedt e.V. (A.M. and P.L.). We thank Kirsten Barre, Linda Carstens, Isabell Wenzel, and Gabriele Feldhoff for excellent technical assistance. We are grateful to the patients for their cooperation. Copyright: Copyright 2018 Elsevier B.V., All rights reserved.",

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Lamprecht, P, Bruhl, H, Erdmann, A, Holl-Ulrich, K, Csernok, E, Seitzer, U, Mack, M, Feller, AC, Reinhold-Keller, E, Gross, WL & Muller, A 2003, 'Differences in CCR5 expression on peripheral blood CD4⁺CD28^- T-cells and in granulomatous lesions between localized and generalized Wegener's granulomatosis', Clinical Immunology, vol. 108, no. 1, pp. 1-7. https://doi.org/10.1016/S1521-6616(03)00121-9

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T1 - Differences in CCR5 expression on peripheral blood CD4+CD28- T-cells and in granulomatous lesions between localized and generalized Wegener's granulomatosis

AU - Lamprecht, Peter

AU - Bruhl, Hilke

AU - Erdmann, Anika

AU - Holl-Ulrich, Konstanze

AU - Csernok, Elena

AU - Seitzer, Ulrike

AU - Mack, Matthias

AU - Feller, Alfred C.

AU - Reinhold-Keller, Eva

AU - Gross, Wolfgang L.

AU - Muller, Antje

N1 - Funding Information: Supported by Grants SFB367/C1 (U.S.) and SFB 367/A8 (P.L., A.M., and W.L.G.) from the German Research Society (Deutsche Forschungsgemeinschaft/DFG), and Grants No. 0.2 and 02.2 from the Verein zur Foerderung der Erforschung und Bekaempfung rheumatischer Erkrankungen Bad Bramstedt e.V. (A.M. and P.L.). We thank Kirsten Barre, Linda Carstens, Isabell Wenzel, and Gabriele Feldhoff for excellent technical assistance. We are grateful to the patients for their cooperation. Copyright: Copyright 2018 Elsevier B.V., All rights reserved.

PY - 2003/7/1

Y1 - 2003/7/1

N2 - Wegener's granulomatosis (WG) is an autoimmune disease characterized by granulomatous lesions and a necrotizing vasculitis. Th1-type-cells lacking CD28 are expanded independent of age and immunosuppressive therapy in WG. To address their migratory properties of CD4+CD28- T-cells we studied the expression of the inducible inflammatory Th1-type chemokine receptor CCR5 in localized WG and generalized WG. Expansion of CD4+CD28- T-cells was more prominent in generalized WG compared to localized WG. In localized WG a larger fraction of CD4+CD28- T-cells displayed CCR5 expression compared to generalized WG. CCR5 expression was also higher in granulomatous lesions in localized WG. Higher levels of CCR5 expression on CD4+CD28- T-cells in localized WG may favor stronger CCR5-mediated recruitment of this T-cell subset into granulomatous lesions in localized WG. Expansion of Th-1-type CD4+CD28-CCR5+ effector memory T-cells might contribute to disease progression and autoreactivity, either directly, by maintaining the inflammatory response, or as a result of bystander activation.

AB - Wegener's granulomatosis (WG) is an autoimmune disease characterized by granulomatous lesions and a necrotizing vasculitis. Th1-type-cells lacking CD28 are expanded independent of age and immunosuppressive therapy in WG. To address their migratory properties of CD4+CD28- T-cells we studied the expression of the inducible inflammatory Th1-type chemokine receptor CCR5 in localized WG and generalized WG. Expansion of CD4+CD28- T-cells was more prominent in generalized WG compared to localized WG. In localized WG a larger fraction of CD4+CD28- T-cells displayed CCR5 expression compared to generalized WG. CCR5 expression was also higher in granulomatous lesions in localized WG. Higher levels of CCR5 expression on CD4+CD28- T-cells in localized WG may favor stronger CCR5-mediated recruitment of this T-cell subset into granulomatous lesions in localized WG. Expansion of Th-1-type CD4+CD28-CCR5+ effector memory T-cells might contribute to disease progression and autoreactivity, either directly, by maintaining the inflammatory response, or as a result of bystander activation.

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