Die vorsorgekoloskopie rettet leben - Ergebnisse der herner vorsorgedatei

Translated title of the contribution: Effectiveness of screening colonoscopy in a community-based study

Dietrich Hüppe*, H. Hartmann, G. Felten, M. Kemen, A. Tannapfel, A. Gillessen, A. Katalinic

*Corresponding author for this work
21 Citations (Scopus)

Abstract

In 2002 screening colonoscopy was introduced in Germany for the prevention of colorectal cancer (CRC) and CRC mortality. Individuals took part in a prospective study from October 2002 until September 2005 performed at a single centre for gastroenterology. Histopathological data, surgical-pathological stages and further follow-up events were recorded until 31st of December 2006. For screened individuals without symptoms, the data obtained were compared to those from age-matched patients who presented with clinical symptoms/signs and who underwent colonoscopy during the same period in time. A total of 5066 individuals underwent screening colonoscopy. In this group, colorectal cancer was detected in 46 individuals (0.9%). Endoscopic treatment was considered adequate for 21 cancers. In this group of 46 patients, 94.5% were classified into UICC stages I-II by pathological staging. In 504 screened individuals, colorectal polyps were detected (12.2%) and removed by polypectomy. Of these polyps, 16 were classified as cancer, 496 as adenomas and 1 as a carcinoid tumour. High grade dysplasia was noted in 41 polyps (8.3% of adenomas). In comparison, 4099 symptomatic patients underwent colonoscopy. In this group 100 cancers (2.4%) were detected. Advanced malignant tumours were noted in 39% of these; endoscopic treatment was feasible in 16% of the cancers. As of December 2006, cancer-related deaths were observed in 20% of symptomatic patients with CRC. Screening colonoscopy detects colorectal cancers in the early stages. Given the favourable prognosis in these stages, screening can reduce CRC-related mortality.

Translated title of the contributionEffectiveness of screening colonoscopy in a community-based study
Original languageGerman
JournalZeitschrift fur Gastroenterologie
Volume46
Issue number2
Pages (from-to)193-200
Number of pages8
ISSN0044-2771
DOIs
Publication statusPublished - 01.02.2008

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