Abstract
Treatment and outcome of 111 patients who fell ill with Wegener's granulomatosis (WG) between 1966 and 1990 were analysed retrospectively. The mean observation time after diagnosis had been 47 (1-288) months. At the time of diagnosis 37 patients suffered from locoregional symptoms only, whereas the disease was generalised in 74 patients. Two regimes of treatment were differentiated: 'conventional' treatment, i.e. daily application of cyclophosphamide/prednisolone (FAUCI scheme) or azathioprine/prednisolone or prednisolone alone, and 'stage-adapted' treatment, characterised by change of different treatments (e.g. cyclophosphamide pulse therapy, cotrimoxazole) according to the extent and activity of disease. In patients who received stage-adapted treatment, relapses occurred significantly more frequently than in conventionally treated patients. On the other hand, lethal outcome was much more frequent in conventionally treated patients.
| Translated title of the contribution | Treatment of Wegener's granulomatosis. Experiences with conventional and stage-adapted treatment of 111 patients for 24 years |
|---|---|
| Original language | German |
| Journal | Zeitschrift fur die Gesamte Innere Medizin und Ihre Grenzgebiete |
| Volume | 48 |
| Issue number | 4 |
| Pages (from-to) | 183-189 |
| Number of pages | 7 |
| ISSN | 0044-2542 |
| Publication status | Published - 1993 |
Research Areas and Centers
- Academic Focus: Center for Infection and Inflammation Research (ZIEL)
