Die rolle des gerinnungssystems bei der entstehung maligner ergüsse

Translated title of the contribution: Coagulation and formation of malignant effusions

Frank Gieseler*, B. Stelck, L. F. Blume, M. Denker, P. Dohrmann, C. Mundhenke, D. Bauerschlag, M. Tiemann, T. Kunze

*Corresponding author for this work
1 Citation (Scopus)


Malignant effusions are a frequent problem for cancer patients. Due to the high resistance of tumor cells within these effusions, no effective treatment has been defined yet. Most patients exhibit additional phenomena related to hyper-coagulability such as elevated levels for d-dimers and prothrombin fragments f1.2; half of them suffer from manifest thrombosis or complications. We followed the hypothesis that the activated coagulation system contributes to the resistance of tumor cells and analyzed the effusions from cancer patients. The majority of isolated tumor cells aberrantly expressed PAR-1 thrombin receptors. In vitro pre-incubation of PAR-1 expressing human leukemia cells with thrombin resulted in a dose-dependent resistance to idarubicin. Within the effusions, we did not only find high concentrations of VEGF and tissue factor, but also all coagulation factors of the tissue factor pathway. Very high levels of prothrombin fragments f1.2 indicate constant thrombin generation. Upon the basis of these findings, we developed a multistep model elucidating the pathophysiological generation of malignant effusions, which might serve as a basis for further examinations.

Translated title of the contributionCoagulation and formation of malignant effusions
Original languageGerman
Issue number4
Pages (from-to)273-277
Number of pages5
Publication statusPublished - 09.2007


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