Die renale Denervation als Therapiestrategie der medikamentös refraktären arteriellen Hypertonie

Translated title of the contribution: Catheter-based renal denervation as a therapeutic approach for resistant hypertension

F. Himmel, F. Bode, K. Mortensen, T. Graf, H. Schunkert, J. Weil*

*Corresponding author for this work


    Arterial hypertension is a major health problem and the leading cause of death worldwide. Only half of all treated hypertensives are controlled to established blood pressure targets. The contribution of renal sympathetic nerve activity to the development and progression of hypertension has been demonstrated. New selective, catheter-based renal denervation shows a very promising non-invasive procedure for the treatment of resistant arterial hypertension. The renal sympathetic denervation treatment uses low-power radiofrequency energy to deactivate the renal nerves, thereby selectively reducing both the pathologic central sympathetic drive to the kidney and the renal contribution to central sympathetic hyperactivity. The catheter-based intervention achieved a durable, clinically important reduction in blood pressure in patients with multi-drug resistant hypertension. This effect has been sustained through at least 24 months without decline in renal function.

    Translated title of the contributionCatheter-based renal denervation as a therapeutic approach for resistant hypertension
    Original languageGerman
    JournalNieren- und Hochdruckkrankheiten
    Issue number3
    Pages (from-to)111-116
    Number of pages6
    Publication statusPublished - 03.2011

    Research Areas and Centers

    • Centers: Cardiological Center Luebeck (UHZL)

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