Problems in the therapeutic cooperation of doctor and patient are recently treated under the heading of patients' noncompliance. This nonmutual term indicates the patients' nonacceptance of doctors' orders. Also in the case of rheumatism the medication-noncompliance can be expected in 25% to 60% - as documented in the literature. Research results so far show that main reasons of noncompliance should not be looked for in the patients alone, e.g. in their badness or madness. In about 70% the noncompliance appears as sensible behaviour. Based upon an own prospective study on the noncompliance of r.a.-patients some research deficits both methodological and empirical are discussed. Finally practical hints to improve doctor-patient-cooperation are given.