Die Blut-Hirn-Schranke und ihre Regulation durch Nf-kB-Signalwege

Translated title of the contribution: The blood-brain barrier and its regulation by NF-kB

Jan Wenzel*, Markus Schwaninger

*Corresponding author for this work


The brain is protected by a tight barrier between blood and parenchyma. This so-called blood-brain barrier protects the brain from invading pathogens, infiltrating immune cells and the extravasation of serum proteins. Beside pericytes and astrocytes mainly endothelial cells form this barrier. Inflammation leads to an increase in the permeability of the blood-brain barrier. NF-kB is activated during inflammation and is a key regulator of inflammatory processes. In brain endothelial cells NF-kB protectsthe blood-brain barrier. Loss of the NF-kB activating protein NEMO in brain endothelial cells leads to endothelial cell death, an increased permeability and epilepsy in mice as well as in humans with the hereditary disease incontinentia pigmenti. Therefore, inflammatory mediators are able to disturb but also to protect the blood-brain barrier.

Translated title of the contributionThe blood-brain barrier and its regulation by NF-kB
Original languageGerman
Issue number2
Pages (from-to)33-44
Number of pages12
Publication statusPublished - 01.05.2016

Research Areas and Centers

  • Academic Focus: Center for Brain, Behavior and Metabolism (CBBM)


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