Die antiadipösen Effekte unter AT1-Rezeptorblockade korrelieren mit einer spezifischen Veränderung des Darmmikrobioms

Translated title of the contribution: The anti-adipose effects of AT1 receptor blockade correlate with a specific change in the gut microbiome

Laura Beckmann

Abstract

The aim of this dissertation is to investigate the possible mechanistic relationship between anti-adipose therapy with the angiotensin II receptor type AT1 blocker (ARB) telmisartan and intestinal microbial colonization in rats fed a high-calorie diet. First, a brief outline of the central health problems of our society and the current state of research on the protective ARB effects (beyond antihypertension) will be described. This will be followed by an outline of the most relevant findings of microbiome research in recent years with regard to diet-induced changes and the causal contribution of the microbiome to obesity and metabolic syndrome.
Translated title of the contributionThe anti-adipose effects of AT1 receptor blockade correlate with a specific change in the gut microbiome
Original languageGerman
QualificationDoctorate / Phd
Awarding Institution
  • University of Luebeck
Supervisors/Advisors
  • Schwaninger, Markus, Supervisor
Award date01.12.2021
Publication statusPublished - 2020

Research Areas and Centers

  • Academic Focus: Center for Brain, Behavior and Metabolism (CBBM)

DFG Research Classification Scheme

  • 204-05 Immunology
  • 204-01 Metabolism, Biochemistry and Genetics of Microorganisms
  • 205-09 Pharmacology
  • 205-17 Endocrinology, Diabetology, Metabolism
  • Otto Roth Award 2022

    Beckmann, Laura (Award Recipient), 07.11.2022

    Prize: Awards of the University of Luebeck

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