Diagnostik und Therapie des primären vitreoretinalen Lymphoms

Translated title of the contribution: Diagnostics and treatment of primary vitreoretinal lymphoma

N. Stübiger*, V. Kakkassery, E. Gundlach, S. Winterhalter, U. Pleyer

*Corresponding author for this work
6 Citations (Scopus)


Background: Primary vitreoretinal lymphoma (PVRL) is a rare ocular lymphoid malignancy, mostly a diffuse large B-cell lymphoma. The PVRL, previously called primary intraocular lymphoma (PIOL), is a subset of primary central nervous system lymphoma (PCNSL). Diagnosis: The diagnosis of PVRL is often difficult as it often mimics chronic intermediate or posterior uveitis; therefore, PVRL requires various procedures for the diagnostics, e.g. immunohistochemistry, cytology, pathology, molecular pathology and cytokine analysis (interleukin 10) after surgically obtaining ocular specimens. Therapy: Treatment forms that are effective for systemic lymphomas have not been reliably successful for PVRL and PCNSL. Current management of PVRL consists of chemotherapy, such as methotrexate or rituximab, possibly combined with external beam radiation whereby both chemotherapeutic agents are administered systemically as well as intravitreally. Intravitreal treatment alone is recommended solely in the case of monocular PVRL, which is highly controversial. A PVRL usually responds well to initial treatment; however, relapse rates and CNS involvement are high, resulting in a poor prognosis and limited survival.

Translated title of the contributionDiagnostics and treatment of primary vitreoretinal lymphoma
Original languageGerman
Issue number3
Pages (from-to)223-230
Number of pages8
Publication statusPublished - 01.03.2015

Research Areas and Centers

  • Research Area: Luebeck Integrated Oncology Network (LION)


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