Since both malignant and benign lesions may occur concomitantly in the same patient, it is of decisive importance not only to detect but to characterize a lesion. This is particularly mandatory if a surgical procedure or multimodal therapy concepts are planned. An abundance of benign and malignant lesions with various appearances in Multi-Slice computed tomography (MSCT) and MR imaging can be found. The advent of Multi-Slice CT has offered the opportunity of multiphasic volume imaging rather than slice imaging. Submillimeter isotropic voxel geometry served as the reference data set to provide useful information in terms of vascular reconstruction, volumetry and 3D-segmental anatomy. Non-specific contrast agents have been used in abdominal CT (iodine) and MR imaging (gadolinium-chelates) for more than two decades. This category of contrast agents mainly addresses the extracellular space. Various efforts have been made over the last decade to develop contrast agents that combine the excellent contrast resolution of MRI with improved tissue specificity. This article discusses the capabilities of modern MSCT and MRI with various contrast media in the detection and differential diagnosis of hepatic neoplasm with regard to visualisation techniques to improve therapy planning.