TY - JOUR
T1 - Diagnostic Value of ATG5, Apo-Lipoprotein B-48, Thyroid Hormones, and Homocysteine in Patients with Alzheimer's Disease
AU - Hoseinlar, Seyedeh Fatemeh
AU - Nikanfar, Masoud
AU - Laghousi, Delara
AU - Darabi, Masoud
AU - Shademan, Behrouz
AU - Nourazarian, Alireza
N1 - Funding Information:
The present study was supported by grants from the Vice Chancellor for Research, Tabriz University of Medical Sciences, Tabriz, IRAN grant no. IR. TBZ-MED. REC.1399.882.
Publisher Copyright:
© 2023 Verlag Klinisches Labor GmbH. All rights reserved.
PY - 2023
Y1 - 2023
N2 - Background: Alzheimer's disease (AD) is the most common form of dementia. In this study, serum levels of auto-phagy-related 5 (ATG5), apolipoprotein B-48, thyroid hormones, and homocysteine were examined in patients with AD to determine their diagnostic and predictive value for early diagnosis and prevention of AD. Materials: For this study, fifty serum samples were obtained from patients with AD and fifty serum samples from healthy controls. Serum levels of ATG 5, apo B48, thyroid hormones, homocysteine, vitamin B12, and folic acid were determined by ELISA. Spectrophotometry was used to determine serum lipid concentrations. Results: The mean age of the case group was 69 ± 6.4 years and that of the control group was 67 ± 4.2 years. There were differences between the control and case groups in serum levels of homocysteine, apo B48, ATG5, hsCRP, LDL, HDL, cholesterol, and VitB12 (p < 0.05). According to the results of the ROC curve, measurements of serum levels of ATG5, homocysteine, and apo B48 have excellent performance in distinguishing patients with Alzhei-mer's disease from patients without AD. Conclusions: This study suggests that the measurement of serum levels of ATG5, homocysteine, and apo B48, along with other available biomarkers, can be helpful in the diagnosis and management of patients with AD in the early stages of their disease.
AB - Background: Alzheimer's disease (AD) is the most common form of dementia. In this study, serum levels of auto-phagy-related 5 (ATG5), apolipoprotein B-48, thyroid hormones, and homocysteine were examined in patients with AD to determine their diagnostic and predictive value for early diagnosis and prevention of AD. Materials: For this study, fifty serum samples were obtained from patients with AD and fifty serum samples from healthy controls. Serum levels of ATG 5, apo B48, thyroid hormones, homocysteine, vitamin B12, and folic acid were determined by ELISA. Spectrophotometry was used to determine serum lipid concentrations. Results: The mean age of the case group was 69 ± 6.4 years and that of the control group was 67 ± 4.2 years. There were differences between the control and case groups in serum levels of homocysteine, apo B48, ATG5, hsCRP, LDL, HDL, cholesterol, and VitB12 (p < 0.05). According to the results of the ROC curve, measurements of serum levels of ATG5, homocysteine, and apo B48 have excellent performance in distinguishing patients with Alzhei-mer's disease from patients without AD. Conclusions: This study suggests that the measurement of serum levels of ATG5, homocysteine, and apo B48, along with other available biomarkers, can be helpful in the diagnosis and management of patients with AD in the early stages of their disease.
UR - http://www.scopus.com/inward/record.url?scp=85150225876&partnerID=8YFLogxK
U2 - 10.7754/Clin.Lab.2022.220614
DO - 10.7754/Clin.Lab.2022.220614
M3 - Journal articles
C2 - 36912305
AN - SCOPUS:85150225876
SN - 1433-6510
VL - 69
SP - 571
EP - 581
JO - Clinical Laboratory
JF - Clinical Laboratory
IS - 3
ER -
