Diagnose eines primären Antiphospholipidsyndroms bei Ulcus cruris unter Marcumar-Therapie

N. Van Beek; N. Schumacher; O. Haase; D. Zillikens; B. Kahle; E. Schmidt

doi:10.1007/s00105-013-2601-6

Diagnose eines primären Antiphospholipidsyndroms bei Ulcus cruris unter Marcumar-Therapie

Translated title of the contribution: Primary antiphospholipid syndrome: Newly developed leg ulcer and history of stroke

N. Van Beek, N. Schumacher, O. Haase, D. Zillikens, B. Kahle, E. Schmidt^*

^*Corresponding author for this work

Clinic of Dermatology, Allergology and Venerology

Abstract

Antiphospholipid syndrome features not only deep vessel thrombosis but also may have cutaneous manifestations such as Raynaud phenomenon, acral necrosis, livedo reticularis, subcutaneous nodules, and leg ulcers. A 72-year-old man presented with a rapidly progressing leg ulcer. He was already on anticoagulation with warfarin due to atrial fibrillation and disclosed a history of stroke with temporary paresis of the left leg. Histopathology of a biopsy of the edge of the ulcer revealed occlusive arteriosclerosis of medium-sized arteries. Serology showed autoantibodies against cardiolipin, β₂- glycoprotein I, and phosphatidylserine which led to the diagnosis of antiphospholipid syndrome. Therapy with low molecular weight heparin, dexamethasone, and azathioprine in combination with stage-adjusted wound care led to complete healing of the ulcer within 5 months.

Translated title of the contribution	Primary antiphospholipid syndrome: Newly developed leg ulcer and history of stroke
Original language	German
Journal	Hautarzt
Volume	64
Issue number	9
Pages (from-to)	666-670
Number of pages	5
ISSN	0017-8470
DOIs	https://doi.org/10.1007/s00105-013-2601-6
Publication status	Published - 01.09.2013

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title = "Diagnose eines prim{\"a}ren Antiphospholipidsyndroms bei Ulcus cruris unter Marcumar-Therapie",

abstract = "Antiphospholipid syndrome features not only deep vessel thrombosis but also may have cutaneous manifestations such as Raynaud phenomenon, acral necrosis, livedo reticularis, subcutaneous nodules, and leg ulcers. A 72-year-old man presented with a rapidly progressing leg ulcer. He was already on anticoagulation with warfarin due to atrial fibrillation and disclosed a history of stroke with temporary paresis of the left leg. Histopathology of a biopsy of the edge of the ulcer revealed occlusive arteriosclerosis of medium-sized arteries. Serology showed autoantibodies against cardiolipin, β2- glycoprotein I, and phosphatidylserine which led to the diagnosis of antiphospholipid syndrome. Therapy with low molecular weight heparin, dexamethasone, and azathioprine in combination with stage-adjusted wound care led to complete healing of the ulcer within 5 months.",

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T1 - Diagnose eines primären Antiphospholipidsyndroms bei Ulcus cruris unter Marcumar-Therapie

AU - Van Beek, N.

AU - Schumacher, N.

AU - Haase, O.

AU - Zillikens, D.

AU - Kahle, B.

AU - Schmidt, E.

PY - 2013/9/1

Y1 - 2013/9/1

N2 - Antiphospholipid syndrome features not only deep vessel thrombosis but also may have cutaneous manifestations such as Raynaud phenomenon, acral necrosis, livedo reticularis, subcutaneous nodules, and leg ulcers. A 72-year-old man presented with a rapidly progressing leg ulcer. He was already on anticoagulation with warfarin due to atrial fibrillation and disclosed a history of stroke with temporary paresis of the left leg. Histopathology of a biopsy of the edge of the ulcer revealed occlusive arteriosclerosis of medium-sized arteries. Serology showed autoantibodies against cardiolipin, β2- glycoprotein I, and phosphatidylserine which led to the diagnosis of antiphospholipid syndrome. Therapy with low molecular weight heparin, dexamethasone, and azathioprine in combination with stage-adjusted wound care led to complete healing of the ulcer within 5 months.

AB - Antiphospholipid syndrome features not only deep vessel thrombosis but also may have cutaneous manifestations such as Raynaud phenomenon, acral necrosis, livedo reticularis, subcutaneous nodules, and leg ulcers. A 72-year-old man presented with a rapidly progressing leg ulcer. He was already on anticoagulation with warfarin due to atrial fibrillation and disclosed a history of stroke with temporary paresis of the left leg. Histopathology of a biopsy of the edge of the ulcer revealed occlusive arteriosclerosis of medium-sized arteries. Serology showed autoantibodies against cardiolipin, β2- glycoprotein I, and phosphatidylserine which led to the diagnosis of antiphospholipid syndrome. Therapy with low molecular weight heparin, dexamethasone, and azathioprine in combination with stage-adjusted wound care led to complete healing of the ulcer within 5 months.

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Diagnose eines primären Antiphospholipidsyndroms bei Ulcus cruris unter Marcumar-Therapie

Abstract

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