TY - JOUR
T1 - Device landing zone calcification and its impact on residual regurgitation after transcatheter aortic valve implantation with different devices
AU - Seiffert, Moritz
AU - Fujita, Buntaro
AU - Avanesov, Maxim
AU - Lunau, Clemens
AU - Schön, Gerhard
AU - Conradi, Lenard
AU - Prashovikj, Emir
AU - Scholtz, Smita
AU - Börgermann, Jochen
AU - Scholtz, Werner
AU - Schäfer, Ulrich
AU - Lund, Gunnar
AU - Ensminger, Stephan
AU - Treede, Hendrik
N1 - Publisher Copyright:
© The Author 2015.
Copyright:
Copyright 2017 Elsevier B.V., All rights reserved.
PY - 2016
Y1 - 2016
N2 - Aims Calcification of the device landing zone is linked to paravalvular regurgitation after transcatheter aortic valve implantation (TAVI). The mechanisms remain incompletely understood and the performance of next-generation transcatheter heart valves (THV) has not been investigated. We evaluated the impact of calcification patterns on residual aortic regurgitation (AR) after TAVI with different THV in patients with severe aortic stenosis. Methods and Results TAVI was performed in 537 patients at two centres. Devices implanted were the Edwards Sapien XT (n 254), Medtronic CoreValve (n 123), JenaValve (n 62), Medtronic Engager (n 56), and Symetis Acurate (n 42) prostheses. Calcification of the device landing zone was retrospectively assessed from contrast-enhanced multidetector computed tomography data and correlated with echocardiographic and clinical data. Calcium volumes of the aortic valve and left-ventricular outflow tract were associated with residual AR: No AR, 604 mm3 (inter-quartile range, IQR 349-916); trace AR, 639 mm3 (IQR 368-948); mild AR, 710 mm3 (IQR 412-2078); moderate AR, 1041 mm3 (IQR 791-1417, P 0.001). Device landing zone calcium, particularly if located in the left-ventricular outflow tract, and a low cover index were predictive of AR. Differences in the incidence of AR were observed with regard to THV type. Higher calcium volume was associated with the need for post-dilation (n 134, median 852 [IQR 342-945] vs. 604 [IQR 542-1207] mm3, P , 0.001). Conclusion Calcification of the device landing zone, particularly if located inferior to the annulus, was independently associated with residual AR after TAVI with all evaluated THV; however, the incidence of paravalvular leakage differed significantly between the devices implanted.
AB - Aims Calcification of the device landing zone is linked to paravalvular regurgitation after transcatheter aortic valve implantation (TAVI). The mechanisms remain incompletely understood and the performance of next-generation transcatheter heart valves (THV) has not been investigated. We evaluated the impact of calcification patterns on residual aortic regurgitation (AR) after TAVI with different THV in patients with severe aortic stenosis. Methods and Results TAVI was performed in 537 patients at two centres. Devices implanted were the Edwards Sapien XT (n 254), Medtronic CoreValve (n 123), JenaValve (n 62), Medtronic Engager (n 56), and Symetis Acurate (n 42) prostheses. Calcification of the device landing zone was retrospectively assessed from contrast-enhanced multidetector computed tomography data and correlated with echocardiographic and clinical data. Calcium volumes of the aortic valve and left-ventricular outflow tract were associated with residual AR: No AR, 604 mm3 (inter-quartile range, IQR 349-916); trace AR, 639 mm3 (IQR 368-948); mild AR, 710 mm3 (IQR 412-2078); moderate AR, 1041 mm3 (IQR 791-1417, P 0.001). Device landing zone calcium, particularly if located in the left-ventricular outflow tract, and a low cover index were predictive of AR. Differences in the incidence of AR were observed with regard to THV type. Higher calcium volume was associated with the need for post-dilation (n 134, median 852 [IQR 342-945] vs. 604 [IQR 542-1207] mm3, P , 0.001). Conclusion Calcification of the device landing zone, particularly if located inferior to the annulus, was independently associated with residual AR after TAVI with all evaluated THV; however, the incidence of paravalvular leakage differed significantly between the devices implanted.
UR - http://www.scopus.com/inward/record.url?scp=84979030736&partnerID=8YFLogxK
U2 - 10.1093/ehjci/jev174
DO - 10.1093/ehjci/jev174
M3 - Journal articles
C2 - 26160399
AN - SCOPUS:84979030736
SN - 2047-2404
VL - 17
SP - 576
EP - 584
JO - European Heart Journal Cardiovascular Imaging
JF - European Heart Journal Cardiovascular Imaging
IS - 5
ER -