TY - JOUR
T1 - Developmental outcome of extremely preterm infants is improved after less invasive surfactant application: Developmental outcome after LISA
AU - Mehler, Katrin
AU - Broer, Alexander
AU - Roll, Claudia
AU - Göpel, Wolfgang
AU - Wieg, Christian
AU - Jahn, Peter
AU - Teig, Norbert
AU - Höhn, Thomas
AU - Welzing, Lars
AU - Vochem, Matthias
AU - Hoppenz, Marc
AU - Bührer, Christoph
AU - Franklin, Jeremy
AU - Roth, Bernhard
AU - Herting, Egbert
AU - Kribs, Angela
N1 - Publisher Copyright:
© 2020 The Authors. Acta Paediatrica published by John Wiley & Sons Ltd on behalf of Foundation Acta Paediatrica
Copyright:
Copyright 2020 Elsevier B.V., All rights reserved.
PY - 2020/9/6
Y1 - 2020/9/6
N2 - Aim: The aim of this study was to evaluate neurocognitive outcome at 24 months of corrected age after less invasive surfactant application (LISA) in preterm infants born at 23-26 weeks of gestational age. Methods: Surviving participants of a LISA trial conducted in 13 German level III neonatal intensive care units were reviewed for assessment of developmental outcome, hearing and vision problems, growth and rehospitalisation days. Maternal depression, breastfeeding rates and socio-economic factors were evaluated as potentially confounding factors. Results: In total, 156/182 infants took part in the study, 78 had received surfactant via LISA and 78 via endotracheal intubation. 22% of LISA infants compared to 42% of intubated infants had a psychomotor development index (PDI) <70 (0.012). A significant difference in mental development index (MDI) was observed in the stratum of more mature infants (25 and 26 weeks of GA). For this group, MDI < 70 was observed in 4% of LISA infants vs 21% of intubated infants (P = 0.008). Conclusion: At 24 months of age, the LISA-treated infants scored less often PDI < 70 and had similar results in MDI. Infants born at 25 and 26 weeks treated with LISA had lower rates of severe disability. LISA is safe and may be superior.
AB - Aim: The aim of this study was to evaluate neurocognitive outcome at 24 months of corrected age after less invasive surfactant application (LISA) in preterm infants born at 23-26 weeks of gestational age. Methods: Surviving participants of a LISA trial conducted in 13 German level III neonatal intensive care units were reviewed for assessment of developmental outcome, hearing and vision problems, growth and rehospitalisation days. Maternal depression, breastfeeding rates and socio-economic factors were evaluated as potentially confounding factors. Results: In total, 156/182 infants took part in the study, 78 had received surfactant via LISA and 78 via endotracheal intubation. 22% of LISA infants compared to 42% of intubated infants had a psychomotor development index (PDI) <70 (0.012). A significant difference in mental development index (MDI) was observed in the stratum of more mature infants (25 and 26 weeks of GA). For this group, MDI < 70 was observed in 4% of LISA infants vs 21% of intubated infants (P = 0.008). Conclusion: At 24 months of age, the LISA-treated infants scored less often PDI < 70 and had similar results in MDI. Infants born at 25 and 26 weeks treated with LISA had lower rates of severe disability. LISA is safe and may be superior.
UR - http://www.scopus.com/inward/record.url?scp=85091421007&partnerID=8YFLogxK
U2 - 10.1111/apa.15565
DO - 10.1111/apa.15565
M3 - Journal articles
C2 - 32892376
AN - SCOPUS:85091421007
SN - 0803-5253
JO - Acta Paediatrica, International Journal of Paediatrics
JF - Acta Paediatrica, International Journal of Paediatrics
ER -