Development of curative therapies for ewing sarcomas by interdisciplinary cooperative groups in Europe

T. Bölling; G. Braun-Munzinger; S. Burdach; G. Calaminus; A. Craft; O. Delattre; M. C.L. Deley; U. Dirksen; B. Dockhorn-Dworniczak; J. Dunst; S. Engel; A. Faldum; B. Fröhlich; H. Gadner; U. Göbel; G. Gosheger; J. Hardes; D. S. Hawkins; L. Hjorth; C. Hoffmann; H. Kovar; J. Kruseova; R. Ladenstein; I. Leuschner; I. J. Lewis; O. Oberlin; M. Paulussen; J. Potratz; A. Ranft; C. Rössig; C. Rübe; R. Sauer; O. Schober; A. Schuck; B. Timmermann; F. Tirode; H. Van Den Berg; F. Van Valen; V. Vieth; N. Willich; W. Winkelmann; J. Whelan; R. B. Womer

doi:10.1055/s-0035-1545263

Development of curative therapies for ewing sarcomas by interdisciplinary cooperative groups in Europe

T. Bölling, G. Braun-Munzinger, S. Burdach, G. Calaminus, A. Craft, O. Delattre, M. C.L. Deley, U. Dirksen, B. Dockhorn-Dworniczak, J. Dunst, S. Engel, A. Faldum, B. Fröhlich, H. Gadner, U. Göbel, G. Gosheger, J. Hardes, D. S. Hawkins, L. Hjorth, C. HoffmannH. Kovar, J. Kruseova, R. Ladenstein, I. Leuschner, I. J. Lewis, O. Oberlin, M. Paulussen, J. Potratz, A. Ranft, C. Rössig^*, C. Rübe, R. Sauer, O. Schober, A. Schuck, B. Timmermann, F. Tirode, H. Van Den Berg, F. Van Valen, V. Vieth, N. Willich, W. Winkelmann, J. Whelan, R. B. Womer

^*Corresponding author for this work

Department of Radiotherapy

9 Citations (Scopus)

Abstract

Curative therapies for Ewing sarcoma have been developed within cooperative groups. Consecutive clinical trials have systematically assessed the impact and timing of local therapy and the activity of cytotoxic drugs and their combinations. They have led to an increase of long-term disease-free survival to around 70% in patients with localized disease. Translational research in ES remains an area in which interdisciplinary and international cooperation is essential for future progress. This article reviews current state-of-the art therapy, with a focus on trials performed in Europe, and summarizes novel strategies to further advance both the cure rates and quality of survival.

Original language	English
Journal	Klinische Padiatrie
Volume	227
Issue number	3
Pages (from-to)	108-115
Number of pages	8
ISSN	0300-8630
DOIs	https://doi.org/10.1055/s-0035-1545263
Publication status	Published - 22.05.2015

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Bölling, T., Braun-Munzinger, G., Burdach, S., Calaminus, G., Craft, A., Delattre, O., Deley, M. C. L., Dirksen, U., Dockhorn-Dworniczak, B., Dunst, J., Engel, S., Faldum, A., Fröhlich, B., Gadner, H., Göbel, U., Gosheger, G., Hardes, J., Hawkins, D. S., Hjorth, L., ... Womer, R. B. (2015). Development of curative therapies for ewing sarcomas by interdisciplinary cooperative groups in Europe. Klinische Padiatrie, 227(3), 108-115. https://doi.org/10.1055/s-0035-1545263

@article{708b4b55bc4d430f8f9c2905617ff915,

title = "Development of curative therapies for ewing sarcomas by interdisciplinary cooperative groups in Europe",

abstract = "Curative therapies for Ewing sarcoma have been developed within cooperative groups. Consecutive clinical trials have systematically assessed the impact and timing of local therapy and the activity of cytotoxic drugs and their combinations. They have led to an increase of long-term disease-free survival to around 70\% in patients with localized disease. Translational research in ES remains an area in which interdisciplinary and international cooperation is essential for future progress. This article reviews current state-of-the art therapy, with a focus on trials performed in Europe, and summarizes novel strategies to further advance both the cure rates and quality of survival.",

author = "T. B{\"o}lling and G. Braun-Munzinger and S. Burdach and G. Calaminus and A. Craft and O. Delattre and Deley, \{M. C.L.\} and U. Dirksen and B. Dockhorn-Dworniczak and J. Dunst and S. Engel and A. Faldum and B. Fr{\"o}hlich and H. Gadner and U. G{\"o}bel and G. Gosheger and J. Hardes and Hawkins, \{D. S.\} and L. Hjorth and C. Hoffmann and H. Kovar and J. Kruseova and R. Ladenstein and I. Leuschner and Lewis, \{I. J.\} and O. Oberlin and M. Paulussen and J. Potratz and A. Ranft and C. R{\"o}ssig and C. R{\"u}be and R. Sauer and O. Schober and A. Schuck and B. Timmermann and F. Tirode and \{Van Den Berg\}, H. and \{Van Valen\}, F. and V. Vieth and N. Willich and W. Winkelmann and J. Whelan and Womer, \{R. B.\}",

year = "2015",

month = may,

day = "22",

doi = "10.1055/s-0035-1545263",

language = "English",

volume = "227",

pages = "108--115",

journal = "Klinische Padiatrie",

issn = "0300-8630",

publisher = "Georg Thieme Verlag",

number = "3",

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Bölling, T, Braun-Munzinger, G, Burdach, S, Calaminus, G, Craft, A, Delattre, O, Deley, MCL, Dirksen, U, Dockhorn-Dworniczak, B, Dunst, J, Engel, S, Faldum, A, Fröhlich, B, Gadner, H, Göbel, U, Gosheger, G, Hardes, J, Hawkins, DS, Hjorth, L, Hoffmann, C, Kovar, H, Kruseova, J, Ladenstein, R, Leuschner, I, Lewis, IJ, Oberlin, O, Paulussen, M, Potratz, J, Ranft, A, Rössig, C, Rübe, C, Sauer, R, Schober, O, Schuck, A, Timmermann, B, Tirode, F, Van Den Berg, H, Van Valen, F, Vieth, V, Willich, N, Winkelmann, W, Whelan, J & Womer, RB 2015, 'Development of curative therapies for ewing sarcomas by interdisciplinary cooperative groups in Europe', Klinische Padiatrie, vol. 227, no. 3, pp. 108-115. https://doi.org/10.1055/s-0035-1545263

TY - JOUR

T1 - Development of curative therapies for ewing sarcomas by interdisciplinary cooperative groups in Europe

AU - Bölling, T.

AU - Braun-Munzinger, G.

AU - Burdach, S.

AU - Calaminus, G.

AU - Craft, A.

AU - Delattre, O.

AU - Deley, M. C.L.

AU - Dirksen, U.

AU - Dockhorn-Dworniczak, B.

AU - Dunst, J.

AU - Engel, S.

AU - Faldum, A.

AU - Fröhlich, B.

AU - Gadner, H.

AU - Göbel, U.

AU - Gosheger, G.

AU - Hardes, J.

AU - Hawkins, D. S.

AU - Hjorth, L.

AU - Hoffmann, C.

AU - Kovar, H.

AU - Kruseova, J.

AU - Ladenstein, R.

AU - Leuschner, I.

AU - Lewis, I. J.

AU - Oberlin, O.

AU - Paulussen, M.

AU - Potratz, J.

AU - Ranft, A.

AU - Rössig, C.

AU - Rübe, C.

AU - Sauer, R.

AU - Schober, O.

AU - Schuck, A.

AU - Timmermann, B.

AU - Tirode, F.

AU - Van Den Berg, H.

AU - Van Valen, F.

AU - Vieth, V.

AU - Willich, N.

AU - Winkelmann, W.

AU - Whelan, J.

AU - Womer, R. B.

PY - 2015/5/22

Y1 - 2015/5/22

N2 - Curative therapies for Ewing sarcoma have been developed within cooperative groups. Consecutive clinical trials have systematically assessed the impact and timing of local therapy and the activity of cytotoxic drugs and their combinations. They have led to an increase of long-term disease-free survival to around 70% in patients with localized disease. Translational research in ES remains an area in which interdisciplinary and international cooperation is essential for future progress. This article reviews current state-of-the art therapy, with a focus on trials performed in Europe, and summarizes novel strategies to further advance both the cure rates and quality of survival.

AB - Curative therapies for Ewing sarcoma have been developed within cooperative groups. Consecutive clinical trials have systematically assessed the impact and timing of local therapy and the activity of cytotoxic drugs and their combinations. They have led to an increase of long-term disease-free survival to around 70% in patients with localized disease. Translational research in ES remains an area in which interdisciplinary and international cooperation is essential for future progress. This article reviews current state-of-the art therapy, with a focus on trials performed in Europe, and summarizes novel strategies to further advance both the cure rates and quality of survival.

UR - https://www.scopus.com/pages/publications/84929575169

U2 - 10.1055/s-0035-1545263

DO - 10.1055/s-0035-1545263

M3 - Scientific review articles

C2 - 25985445

AN - SCOPUS:84929575169

SN - 0300-8630

VL - 227

SP - 108

EP - 115

JO - Klinische Padiatrie

JF - Klinische Padiatrie

IS - 3

ER -

Development of curative therapies for ewing sarcomas by interdisciplinary cooperative groups in Europe

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