Development and applications of photo-triggered theranostic agents

Prakash Rai; Srivalleesha Mallidi; Xiang Zheng; Ramtin Rahmanzadeh; Youssef Mir; Stefan Elrington; Ahmat Khurshid; Tayyaba Hasan

doi:10.1016/j.addr.2010.09.002

Development and applications of photo-triggered theranostic agents

Prakash Rai, Srivalleesha Mallidi, Xiang Zheng, Ramtin Rahmanzadeh, Youssef Mir, Stefan Elrington, Ahmat Khurshid, Tayyaba Hasan^*

^*Corresponding author for this work

Institute of Biomedical Optics

483 Citations (Scopus)

Abstract

Theranostics, the fusion of therapy and diagnostics for optimizing efficacy and safety of therapeutic regimes, is a growing field that is paving the way towards the goal of personalized medicine for the benefit of patients. The use of light as a remote-activation mechanism for drug delivery has received increased attention due to its advantages in highly specific spatial and temporal control of compound release. Photo-triggered theranostic constructs could facilitate an entirely new category of clinical solutions which permit early recognition of the disease by enhancing contrast in various imaging modalities followed by the tailored guidance of therapy. Finally, such theranostic agents could aid imaging modalities in monitoring response to therapy. This article reviews recent developments in the use of light-triggered theranostic agents for simultaneous imaging and photoactivation of therapeutic agents. Specifically, we discuss recent developments in the use of theranostic agents for photodynamic-, photothermal- or photo-triggered chemotherapy for several diseases.

Original language	English
Journal	Advanced Drug Delivery Reviews
Volume	62
Issue number	11
Pages (from-to)	1094-1124
Number of pages	31
ISSN	0169-409X
DOIs	https://doi.org/10.1016/j.addr.2010.09.002
Publication status	Published - 30.08.2010

Funding

We would like to thank Prof. Gang Zheng and his postdoctoral fellow Dr. Klara Stefflova for their help with making Fig. 2 of this manuscript. We would also like to thank Dr. Bryan Spring for his helpful suggestions. This work was supported by National Institutes of Health Grant Numbers P01 CA084203 and R44CA128364 National Cancer Institute/National Institutes of Health Grant Numbers R01 CA119388 and RC1 CA146337 , the Department of Defense Air Force Office of Scientific Research FA9550-04-1-0079 , and the Wellman Center for Photomedicine core funds. Y.M. acknowledges funding from Fonds québécois de la recherche sur la nature et les technologies (FQRNT), Québec, Canada . A.K. would like to acknowledge funding from the Higher Education Commission (HEC) of Pakistan .

UN SDGs

This output contributes to the following UN Sustainable Development Goals (SDGs)

SDG 9 Industry, Innovation, and Infrastructure

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10.1016/j.addr.2010.09.002

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AU - Mir, Youssef

AU - Elrington, Stefan

AU - Khurshid, Ahmat

AU - Hasan, Tayyaba

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Development and applications of photo-triggered theranostic agents

Abstract

Funding

UN SDGs

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