TY - JOUR
T1 - Development and applications of photo-triggered theranostic agents
AU - Rai, Prakash
AU - Mallidi, Srivalleesha
AU - Zheng, Xiang
AU - Rahmanzadeh, Ramtin
AU - Mir, Youssef
AU - Elrington, Stefan
AU - Khurshid, Ahmat
AU - Hasan, Tayyaba
PY - 2010/8/30
Y1 - 2010/8/30
N2 - Theranostics, the fusion of therapy and diagnostics for optimizing efficacy and safety of therapeutic regimes, is a growing field that is paving the way towards the goal of personalized medicine for the benefit of patients. The use of light as a remote-activation mechanism for drug delivery has received increased attention due to its advantages in highly specific spatial and temporal control of compound release. Photo-triggered theranostic constructs could facilitate an entirely new category of clinical solutions which permit early recognition of the disease by enhancing contrast in various imaging modalities followed by the tailored guidance of therapy. Finally, such theranostic agents could aid imaging modalities in monitoring response to therapy. This article reviews recent developments in the use of light-triggered theranostic agents for simultaneous imaging and photoactivation of therapeutic agents. Specifically, we discuss recent developments in the use of theranostic agents for photodynamic-, photothermal- or photo-triggered chemotherapy for several diseases.
AB - Theranostics, the fusion of therapy and diagnostics for optimizing efficacy and safety of therapeutic regimes, is a growing field that is paving the way towards the goal of personalized medicine for the benefit of patients. The use of light as a remote-activation mechanism for drug delivery has received increased attention due to its advantages in highly specific spatial and temporal control of compound release. Photo-triggered theranostic constructs could facilitate an entirely new category of clinical solutions which permit early recognition of the disease by enhancing contrast in various imaging modalities followed by the tailored guidance of therapy. Finally, such theranostic agents could aid imaging modalities in monitoring response to therapy. This article reviews recent developments in the use of light-triggered theranostic agents for simultaneous imaging and photoactivation of therapeutic agents. Specifically, we discuss recent developments in the use of theranostic agents for photodynamic-, photothermal- or photo-triggered chemotherapy for several diseases.
UR - http://www.scopus.com/inward/record.url?scp=78650696318&partnerID=8YFLogxK
U2 - 10.1016/j.addr.2010.09.002
DO - 10.1016/j.addr.2010.09.002
M3 - Scientific review articles
C2 - 20858520
AN - SCOPUS:78650696318
SN - 0169-409X
VL - 62
SP - 1094
EP - 1124
JO - Advanced Drug Delivery Reviews
JF - Advanced Drug Delivery Reviews
IS - 11
ER -
