Determination of the brain-blood partition coefficient for water in mice using MRI

Christoph Leithner; Susanne Müller; Martina Füchtemeier; Ute Lindauer; Ulrich Dirnagl; Georg Royl

doi:10.1038/jcbfm.2010.160

Determination of the brain-blood partition coefficient for water in mice using MRI

Christoph Leithner^*, Susanne Müller, Martina Füchtemeier, Ute Lindauer, Ulrich Dirnagl, Georg Royl

^*Corresponding author for this work

Department of Neurology

40 Citations (Scopus)

Abstract

Cerebral blood flow (CBF) quantification is a valuable tool in stroke research. Mice are of special interest because of the potential of genetic engineering. Magnetic resonance imaging (MRI) provides repetitive, noninvasive CBF quantification. Many MRI techniques require the knowledge of the brain-blood partition coefficient (BBPC) for water. Adopting an MRI protocol described by Roberts et al (1996) in humans, we determined the BBPC for water in 129S6/SvEv mice from proton density measurements of brain and blood, calibrated with deuterium oxide/water phantoms. The average BBPC for water was 0.89±0.03 mL/g, with little regional variation within the mouse brain.

Original language	English
Journal	Journal of Cerebral Blood Flow and Metabolism
Volume	30
Issue number	11
Pages (from-to)	1821-1824
Number of pages	4
ISSN	0271-678X
DOIs	https://doi.org/10.1038/jcbfm.2010.160
Publication status	Published - 01.11.2010

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This output contributes to the following UN Sustainable Development Goals (SDGs)

SDG 3 Good Health and Well-being
SDG 10 Reduced Inequalities

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10.1038/jcbfm.2010.160

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abstract = "Cerebral blood flow (CBF) quantification is a valuable tool in stroke research. Mice are of special interest because of the potential of genetic engineering. Magnetic resonance imaging (MRI) provides repetitive, noninvasive CBF quantification. Many MRI techniques require the knowledge of the brain-blood partition coefficient (BBPC) for water. Adopting an MRI protocol described by Roberts et al (1996) in humans, we determined the BBPC for water in 129S6/SvEv mice from proton density measurements of brain and blood, calibrated with deuterium oxide/water phantoms. The average BBPC for water was 0.89±0.03 mL/g, with little regional variation within the mouse brain.",

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AU - Müller, Susanne

AU - Füchtemeier, Martina

AU - Lindauer, Ute

AU - Dirnagl, Ulrich

AU - Royl, Georg

PY - 2010/11/1

Y1 - 2010/11/1

N2 - Cerebral blood flow (CBF) quantification is a valuable tool in stroke research. Mice are of special interest because of the potential of genetic engineering. Magnetic resonance imaging (MRI) provides repetitive, noninvasive CBF quantification. Many MRI techniques require the knowledge of the brain-blood partition coefficient (BBPC) for water. Adopting an MRI protocol described by Roberts et al (1996) in humans, we determined the BBPC for water in 129S6/SvEv mice from proton density measurements of brain and blood, calibrated with deuterium oxide/water phantoms. The average BBPC for water was 0.89±0.03 mL/g, with little regional variation within the mouse brain.

AB - Cerebral blood flow (CBF) quantification is a valuable tool in stroke research. Mice are of special interest because of the potential of genetic engineering. Magnetic resonance imaging (MRI) provides repetitive, noninvasive CBF quantification. Many MRI techniques require the knowledge of the brain-blood partition coefficient (BBPC) for water. Adopting an MRI protocol described by Roberts et al (1996) in humans, we determined the BBPC for water in 129S6/SvEv mice from proton density measurements of brain and blood, calibrated with deuterium oxide/water phantoms. The average BBPC for water was 0.89±0.03 mL/g, with little regional variation within the mouse brain.

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JO - Journal of Cerebral Blood Flow and Metabolism

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ER -

Determination of the brain-blood partition coefficient for water in mice using MRI

Abstract

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