TY - JOUR
T1 - Determination of the brain-blood partition coefficient for water in mice using MRI
AU - Leithner, Christoph
AU - Müller, Susanne
AU - Füchtemeier, Martina
AU - Lindauer, Ute
AU - Dirnagl, Ulrich
AU - Royl, Georg
PY - 2010/11/1
Y1 - 2010/11/1
N2 - Cerebral blood flow (CBF) quantification is a valuable tool in stroke research. Mice are of special interest because of the potential of genetic engineering. Magnetic resonance imaging (MRI) provides repetitive, noninvasive CBF quantification. Many MRI techniques require the knowledge of the brain-blood partition coefficient (BBPC) for water. Adopting an MRI protocol described by Roberts et al (1996) in humans, we determined the BBPC for water in 129S6/SvEv mice from proton density measurements of brain and blood, calibrated with deuterium oxide/water phantoms. The average BBPC for water was 0.89±0.03 mL/g, with little regional variation within the mouse brain.
AB - Cerebral blood flow (CBF) quantification is a valuable tool in stroke research. Mice are of special interest because of the potential of genetic engineering. Magnetic resonance imaging (MRI) provides repetitive, noninvasive CBF quantification. Many MRI techniques require the knowledge of the brain-blood partition coefficient (BBPC) for water. Adopting an MRI protocol described by Roberts et al (1996) in humans, we determined the BBPC for water in 129S6/SvEv mice from proton density measurements of brain and blood, calibrated with deuterium oxide/water phantoms. The average BBPC for water was 0.89±0.03 mL/g, with little regional variation within the mouse brain.
UR - http://www.scopus.com/inward/record.url?scp=78049473090&partnerID=8YFLogxK
U2 - 10.1038/jcbfm.2010.160
DO - 10.1038/jcbfm.2010.160
M3 - Journal articles
C2 - 20842161
AN - SCOPUS:78049473090
VL - 30
SP - 1821
EP - 1824
JO - Journal of Cerebral Blood Flow and Metabolism
JF - Journal of Cerebral Blood Flow and Metabolism
SN - 0271-678X
IS - 11
ER -