Abstract
A mixture of different conformers of the flexible tetrasaccharide sialyl Lewisx is presented in solution to the E‐selectin receptor, which binds only one conformation, as shown by NMR spectroscopy. The experimentally determined transfer NOEs can be used to derive proton–proton distance restrictions, which together with the confomer ensemble obtained by Metropolis Monte Carlo simulations, can be used to determine the conformation of sialyl Lewisx in the complexed state. (Figure Presented.)
Original language | English |
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Journal | Angewandte Chemie International Edition in English |
Volume | 34 |
Issue number | 17 |
Pages (from-to) | 1841-1844 |
Number of pages | 4 |
ISSN | 0570-0833 |
DOIs | |
Publication status | Published - 15.09.1995 |