Desynchronizing effect of high-frequency stimulation in a generic cortical network model

Markus Schütt, Jens Christian Claussen


Transcranial electrical stimulation (TCES) and deep brain stimulation are two different applications of electrical current to the brain used in different areas of medicine. Both have a similar frequency dependence of their efficiency, with the most pronounced effects around 100 Hz. We apply superthreshold electrical stimulation, specifically depolarizing DC current, interrupted at different frequencies, to a simple model of a population of cortical neurons which uses phenomenological descriptions of neurons by Izhikevich and synaptic connections on a similar level of sophistication. With this model, we are able to reproduce the optimal desynchronization around 100 Hz, as well as to predict the full frequency dependence of the efficiency of desynchronization, and thereby to give a possible explanation for the action mechanism of TCES.
Original languageEnglish
JournalCognitive Neurodynamics
Issue number4
Pages (from-to)343-351
Number of pages9
Publication statusPublished - 10.04.2012


Dive into the research topics of 'Desynchronizing effect of high-frequency stimulation in a generic cortical network model'. Together they form a unique fingerprint.

Cite this